Drug profile

The FDA adverse-event record for Ciprofloxacin

185 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ciprofloxacin. See the species affected, top reactions, and outcomes below.

185
adverse-event reports
10.8%
death-coded share
Dog
most-reported species
32
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
185
Total Reports
20
Deaths Reported
10.8%
Death Rate

Active Ingredients

Ciprofloxacin

Administration Routes

OralUnknownOphthalmicIntraocularIntravenousAuricular (Otic)

Species Affected

Dog 167
Cat 13
Human 2
Parrot 2
Horse 1

Most Affected Breeds

Retriever - Labrador 23
Shepherd Dog - German 10
Dog (unknown) 7
Pit Bull 7
Retriever - Golden 7
Unknown 6
Chihuahua 6
Boxer (German Boxer) 6
Chow Chow 5
Rottweiler 5

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 32
Vomiting 31
Emesis 30
Other abnormal test result NOS 23
Diarrhoea 20
Lack of efficacy - NOS 17
Elevated alanine aminotransferase (ALT) 15
Elevated serum alkaline phosphatase (SAP) 14
Death by euthanasia 13
Anorexia 12
Weight loss 12
Not eating 10

Outcome Breakdown

Recovered/Normal
67 (36.6%)
Outcome Unknown
55 (30.1%)
Ongoing
33 (18.0%)
Euthanized
13 (7.1%)
Recovered with Sequela
8 (4.4%)
Died
7 (3.8%)

Ciprofloxacin Adverse Event Insights

185 reports name Ciprofloxacin; 20 recorded a death outcome (10.8% of reported events, not a population-level mortality rate). Active ingredient: Ciprofloxacin. Administration routes: Oral, Unknown, Ophthalmic, Intraocular.

By species: Dog (167 reports), Cat (13 reports), Human (2 reports). By breed: Retriever - Labrador (23), Shepherd Dog - German (10), Dog (unknown) (7).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (32), Vomiting (31), Emesis (30), Other abnormal test result NOS (23). Outcome, 183 coded reports: Recovered/Normal leads at 36.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.