Drug profile

The FDA adverse-event record for Chlortetracycline Calcium Complex (Biomass)

76 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Chlortetracycline Calcium Complex (Biomass). See the species affected, top reactions, and outcomes below.

76
adverse-event reports
53.9%
death-coded share
Cattle
most-reported species
35
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
76
Total Reports
41
Deaths Reported
53.9%
Death Rate

Active Ingredients

Chlortetracycline Calcium Complex (Biomass)

Administration Routes

OralUnknownSubcutaneous

Species Affected

Cattle 53
Unknown 19
Horse 2
Chicken 1
Pig 1

Most Affected Breeds

Mixed (Cattle) 44
Unknown 19
Cattle (other) 5
Aberdeen Angus 2
Horse (unknown) 2
Chicken (unknown) 1
Holstein-Friesian also known as Holstein 1
Pig (unknown) 1
Hereford cattle 1

Most Reported Reactions

Death 35
Lack of efficacy - NOS 32
INEFFECTIVE, ANTIBIOTIC 15
Color, Abnormal 5
Containers, Damaged 4
Closure, Abnormal 3
Death by euthanasia 3
CULTURE/TITER DATA ABNORMAL 3
Appearance, Abnormal 3
Odor, Abnormal 2
Underdose 2
Contamination, Foreign Object 2

Outcome Breakdown

Died
39 (42.4%)
Outcome Unknown
35 (38.0%)
Recovered/Normal
6 (6.5%)
Ongoing
5 (5.4%)
Euthanized
4 (4.3%)
Recovered with Sequela
3 (3.3%)

Chlortetracycline Calcium Complex (Biomass) Adverse Event Insights

76 reports name Chlortetracycline Calcium Complex (Biomass); 41 recorded a death outcome (53.9% of reported events, not a population-level mortality rate). Active ingredient: Chlortetracycline Calcium Complex (Biomass). Administration routes: Oral, Unknown, Subcutaneous.

By species: Cattle (53 reports), Unknown (19 reports), Horse (2 reports). By breed: Mixed (Cattle) (44), Unknown (19), Cattle (other) (5).

Leading clinical signs: Death (35), Lack of efficacy - NOS (32), INEFFECTIVE, ANTIBIOTIC (15), Color, Abnormal (5). Outcome, 92 coded reports: Died leads at 42.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.