Drug profile

The FDA adverse-event record for Atipamezole Hydrochloride

1,561 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Atipamezole Hydrochloride. See the species affected, top reactions, and outcomes below.

1,561
adverse-event reports
17.0%
death-coded share
Dog
most-reported species
189
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,561
Total Reports
266
Deaths Reported
17.0%
Death Rate

Active Ingredients

Atipamezole Hydrochloride

Administration Routes

IntramuscularUnknownIntravenousSubcutaneousParenteralOtherIntraperitonealOphthalmicOral

Species Affected

Dog 980
Cat 439
Unknown 111
Rabbit 4
Human 4
Other Rodents 3
Tiger 2
Mouse 2
Chinchilla 2
Rat 2

Most Affected Breeds

Domestic Shorthair 242
Unknown 133
Retriever - Labrador 119
Dog (unknown) 85
Terrier - Bull - American Pit 60
Domestic Longhair 52
Shepherd Dog - German 45
Cat (other) 37
Cat (unknown) 31
Retriever - Golden 30

Most Reported Reactions

Death 189
INEFFECTIVE, REVERSAL 182
Bradycardia 168
Lack of efficacy - NOS 154
Vomiting 139
Lethargy (see also Central nervous system depression in 'Neurological') 124
Sedation prolonged 121
Hypersalivation 116
Cardiac arrest 103
Panting 96
Diarrhoea 94
Seizure NOS 87

Outcome Breakdown

Ongoing
577 (39.4%)
Recovered/Normal
478 (32.6%)
Died
206 (14.1%)
Outcome Unknown
140 (9.6%)
Euthanized
62 (4.2%)
Recovered with Sequela
2 (0.1%)

Atipamezole Hydrochloride Adverse Event Insights

1,561 reports name Atipamezole Hydrochloride; 266 recorded a death outcome (17.0% of reported events, not a population-level mortality rate). Active ingredient: Atipamezole Hydrochloride. Administration routes: Intramuscular, Unknown, Intravenous, Subcutaneous.

By species: Dog (980 reports), Cat (439 reports), Unknown (111 reports). By breed: Domestic Shorthair (242), Unknown (133), Retriever - Labrador (119).

Leading clinical signs: Death (189), INEFFECTIVE, REVERSAL (182), Bradycardia (168), Lack of efficacy - NOS (154). Outcome, 1,465 coded reports: Ongoing leads at 39.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.