Drug profile

The FDA adverse-event record for Atipamezole Hydrochloride

1,655 FDA reports name Atipamezole Hydrochloride, a high-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#129 of 2,679
by report volume (all drugs)
1,655
adverse-event reports
17.0%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Atipamezole Hydrochloride ranks #129 of 2679 by total reports (1,655) and #303 of 1130 by death-coded share (17.0%). National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#129
This drug, reports of 2679
#303
This drug, death share of 1130

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Atipamezole Hydrochloride has 1,655 reports now versus 1,609 in that prior snapshot: 46 more (2.9%).

Report change
+46
Death-coded reports
+7
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Atipamezole Hydrochloride changes

Signature read: death-coded report count at 282 is the most distinctive stamp on Atipamezole Hydrochloride's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
1,655
Total Reports
282
Deaths Reported
17.0%
Death-coded share of reports

Active Ingredients

Atipamezole Hydrochloride

Administration Routes

IntramuscularUnknownIntravenousParenteralSubcutaneousOtherIntraperitonealOphthalmicOral

Species Affected

Dog 1,032
Cat 477
Unknown 115
Rabbit 4
Human 4
Other Rodents 3
Tiger 2
Mouse 2
Chinchilla 2
Rat 2

Most Affected Breeds

Domestic Shorthair 267
Unknown 138
Retriever - Labrador 124
Dog (unknown) 86
Terrier - Bull - American Pit 66
Domestic Longhair 55
Shepherd Dog - German 48
Cat (other) 38
Cat (unknown) 32
Retriever - Golden 31

Most Reported Reactions

Death 203
INEFFECTIVE, REVERSAL 182
Bradycardia 173
Lack of efficacy - NOS 155
Vomiting 145
Sedation prolonged 125
Hypersalivation 124
Lethargy (see also Central nervous system depression in 'Neurological') 124
Cardiac arrest 106
Diarrhoea 105
Panting 100
Seizure NOS 92

Outcome Breakdown

Ongoing
621 (39.9%)
Recovered/Normal
493 (31.7%)
Died
220 (14.1%)
Outcome Unknown
155 (10.0%)
Euthanized
64 (4.1%)
Recovered with Sequela
2 (0.1%)

Atipamezole Hydrochloride: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

High-volume nationwide drug peers

Two openFDA-derived peer sets for Atipamezole Hydrochloride, both floored at ≥50 reports so the neighborhoods stay in the advertised mass.

Similar death-coded share

Nearest other drugs by death-coded share (17.0% here), distinct from the volume row.

What to do with this drug

  • Compare Atipamezole Hydrochloride's report volume and death-coded share against similar drugs nationwide. See similar drugs
  • Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
  • Browse the full drug directory to compare report counts across products. All drugs

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Atipamezole Hydrochloride (#129 of 2,679 by report volume); death-coded 17.0%. PlainBreed drug row · death-coded report count stamp 282 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →