Total Reports
14
FDA CVM filings
Horse /
FDA CVM · 2025 release 14 reports on file
Shire - FDA Adverse Event Profile
Adverse-event records for Shire (Horse) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 14 reports on file, Shire sits at #398 among horse breeds by volume; death-coded share is 28.6% (4 reports).
- #398
- most-reported horse breed
- 28.6%
- death-coded report share
- 4
- Death - top reaction
- 13.6 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
4
of 14 reports
Death Rate
28.6%
death-coded share
Avg Age at Report
13.6 yr
238.1 kg avg weight
Death-Coded Outcome Share
Shire death-coded reports 28.6%
Cross-breed median
28.6% of 14 shire reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 238.1 kg (525.0 lbs)
Top Reported Reactions
Death 4
INEFFECTIVE, PINWORMS 2
Fever 2
No sign 1
Reluctant to move 1
Most Referenced Drugs
Butorphanol Tartrate 3
Detomidine Hydrochloride 3
Hyoscine Butylbromide 3
Xylazine 3
Ceftiofur 2
Outcome Breakdown
Recovered/Normal
4 (33.3%)
Died
4 (33.3%)
Outcome Unknown
3 (25.0%)
Ongoing
1 (8.3%)
Gender Distribution
Female 6 (42.9%)
Male 6 (42.9%)
Unknown 1 (7.1%)
Mixed 1 (7.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 2 | |
| 2013 | 1 | |
| 2015 | 2 | |
| 2017 | 1 | |
| 2021 | 2 | |
| 2022 | 1 | |
| 2023 | 1 | |
| 2025 | 4 | |
Shire Pet Health Insights
Shire accounts for 14 FDA adverse event reports, ranking #398 by volume among horse breeds, with 4 reports (28.6%) coded as a death outcome. Mean age at report: 13.6 years, average weight 238.1 kg (525.0 lbs).
Top reported signs: Death (4), INEFFECTIVE, PINWORMS (2), Fever (2). Most-referenced drug: Butorphanol Tartrate (3 reports), followed by Detomidine Hydrochloride (3) and Hyoscine Butylbromide (3).
Outcome coding on 12 status-recorded reports is dominated by Recovered/Normal (33.3%). Annual submissions ranged 2,010-2,025 across 8 years on file.
Horse Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Shire? ▼
There are 14 adverse event reports involving Shire in the FDA database, with 4 reports involving death (28.6% death rate). Shire ranks #398 by report volume.
What are the most common adverse reactions reported for Shire? ▼
The most commonly reported adverse reactions for Shire are Death (4 reports), INEFFECTIVE, PINWORMS (2 reports), Fever (2 reports), No sign (1 reports), Reluctant to move (1 reports).
What drugs are most frequently associated with Shire adverse events? ▼
The drugs most frequently referenced in Shire adverse event reports are Butorphanol Tartrate (3 reports), Detomidine Hydrochloride (3 reports), Hyoscine Butylbromide (3 reports), Xylazine (3 reports), Ceftiofur (2 reports).
What is the average age of Shire in adverse event reports? ▼
The average age of Shire at the time of adverse event reports is 13.6 years, with an average weight of 238.1 kg (525.0 lbs).
Does a high number of adverse event reports mean Shire is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Shire safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.