Reaction profile

The FDA adverse-event record for wheal

110 FDA adverse-event reports reference wheal (VeDDRA 520). See the species, breeds, and drugs most associated with it below.

110
reports citing this reaction
0.9%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
110
Total Reports
1
Deaths
0.9%
Death Rate

Species Most Affected

Dog 98
Horse 7
Cat 2
Cattle 2
Human 1

Breeds Most Affected

Terrier - Bull - American Pit 10
Chihuahua 8
Retriever - Labrador 8
Dachshund (unspecified) 6
Boxer (German Boxer) 5
Terrier - Rat 3
Terrier - Boston 3
Terrier (unspecified) 3
Terrier - Bull - Staffordshire 3
Crossbred Canine/dog 3

Associated Drugs

Moxidectin 24
Oclacitinib Maleate 10
Anti-Il31 Mab Mcs Lot #1283563 9
Afoxolaner 7
Maropitant Citrate 7
Prednisone 6
Imidacloprid + Moxidectin 5
Spinosad 5
Cefovecin 5
Milbemycin Oxime + Spinosad 5
Fluralaner Chew Tablets 5
Cephalexin 5
Hyaluronate Sodium 3
Pentosan 3
Ivermectin + Pyrantel Pamoate 3
Cyclosporine A 3
Melarsomine Dihydrochloride Injection 3
Diphenhydramine 3
Metronidazole 3
Carprofen 3

Wheal Reaction Insights

110 reports name Wheal; 1 recorded a death outcome (0.9% of reported events, not a population-level mortality rate). VeDDRA code: 520.

By species: Dog (98 reports), Horse (7 reports), Cat (2 reports). By breed: Terrier - Bull - American Pit (10), Chihuahua (8), Retriever - Labrador (8).

Most co-reported drugs: Moxidectin (24 reports), Oclacitinib Maleate (10 reports), Anti-Il31 Mab Mcs Lot #1283563 (9 reports), Afoxolaner (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.