Reaction profile

The FDA adverse-event record for vagal shock

11 FDA reports name vagal shock, a lower-volume reaction in the CVM extract (VeDDRA 2381). Plate stamps and neighbourhood peers follow.

#2442 of 2,481
by report volume (all reactions)
11
reports citing this reaction
18.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vagal shock has 11 reports now versus 10 in that prior snapshot: 1 more (10.0%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vagal shock changes

FDA AER · VeDDRA plate

Code 2381 VOL-TRACE

VOL-TRACE · DEATH-ELEV · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 11 reports
  • DEATH-ELEV 18.2%
  • BOTTOM-DECILE #2442/2481
  • PHOTO-FINISH ABNORMAL PANCREATIC S…
  • SPECIES-DOG Dog · 10
  • DRUG-LEAD Pimobendan · 2
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Vagal shock

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ABNORMAL PANCREATIC S… · near11Aortic stenosis · near11Aqueous flare · near11Bile duct inflammation · near11Vagal shock · this reaction11Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Vagal shock

What the FDA AER plate says about Vagal shock

Signature read: 11 reports place Vagal shock in the lower third of FDA AER volume (#2442 of 2,481). Report volume is lower-third scale: 11 named reports in the openFDA extract. 2 of 11 reports were death-coded (18.2% of named reports, not a population mortality rate). Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports). Lead species Dog (10). Lead co-reported drug Pimobendan (2).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pimobendan appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 10
Cat 1

Breeds Most Affected

Retriever - Labrador 2
Sheepdog - Beauce (Beauceron) 1
Terrier - Yorkshire 1
Chihuahua 1
Sphynx 1
Maltese 1
Crossbred Canine/dog 1
Terrier - Bull - Staffordshire 1
Retriever - Golden 1
Shih Tzu 1

Associated Drugs

Pimobendan 2
Ivermectin + Pyrantel As Pamoate Salt 2
Moxidectin 2
Melarsomine Dihydrochloride Injection 1
Afoxolaner 28.3 Mg Chewable Tablets 1
Eurican Chppi2Lr-Nf 1
Dolthene Oral Solution 1
Maropitant Citrate 1
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1
Diphenhydramine Hcl 1
Dexamethasone Sodium Phosphate 1
Metronidazole 1
Prebiotics, Microorganisms 1
Ivermectin + Pyrantel 1
Pcso-524 1
Afoxolaner 1
Dapp Vaccine 1
Bordetella Vaccine 1
Rabies Vaccine 1
Sarolaner 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vagal shock (#2442 of 2,481 by report volume); death-coded 18.2%. PlainBreed reaction plate · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →