Reaction profile

The FDA adverse-event record for vagal shock

10 FDA adverse-event reports reference vagal shock (VeDDRA 2381). See the species, breeds, and drugs most associated with it below.

10
reports citing this reaction
20.0%
death-coded share
Dog
most-affected species
Pimobendan
most-associated drug
Verify with FDA CVM →
10
Total Reports
2
Deaths
20.0%
Death Rate

Species Most Affected

Dog 9
Cat 1

Breeds Most Affected

Retriever - Labrador 2
Sheepdog - Beauce (Beauceron) 1
Terrier - Yorkshire 1
Chihuahua 1
Sphynx 1
Maltese 1
Crossbred Canine/dog 1
Terrier - Bull - Staffordshire 1
Retriever - Golden 1

Associated Drugs

Pimobendan 2
Ivermectin + Pyrantel As Pamoate Salt 2
Moxidectin 2
Melarsomine Dihydrochloride Injection 1
Afoxolaner 28.3 Mg Chewable Tablets 1
Eurican Chppi2Lr-Nf 1
Dolthene Oral Solution 1
Maropitant Citrate 1
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1
Diphenhydramine Hcl 1
Dexamethasone Sodium Phosphate 1
Metronidazole 1
Prebiotics, Microorganisms 1
Ivermectin + Pyrantel 1
Pcso-524 1
Afoxolaner 1
Dapp Vaccine 1
Bordetella Vaccine 1
Rabies Vaccine 1
Sarolaner 1

Vagal shock Reaction Insights

10 reports name Vagal shock; 2 recorded a death outcome (20.0% of reported events, not a population-level mortality rate). VeDDRA code: 2381.

By species: Dog (9 reports), Cat (1 reports). By breed: Retriever - Labrador (2), Sheepdog - Beauce (Beauceron) (1), Terrier - Yorkshire (1).

Most co-reported drugs: Pimobendan (2 reports), Ivermectin + Pyrantel As Pamoate Salt (2 reports), Moxidectin (2 reports), Melarsomine Dihydrochloride Injection (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.