Reaction profile

The FDA adverse-event record for abnormal pancreatic specific lipase (pli)

11 FDA reports name abnormal pancreatic specific lipase (pli), a lower-volume reaction in the CVM extract (VeDDRA 93049). Plate stamps and neighbourhood peers follow.

#2405 of 2,481
by report volume (all reactions)
11
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) has 11 reports now versus 11 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) changes

FDA AER · VeDDRA plate

Code 93049 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 11 reports
  • DEATH-HOT 27.3%
  • BOTTOM-DECILE #2405/2481
  • PHOTO-FINISH Aortic stenosis
  • SPECIES-DOG Dog · 7
  • DRUG-LEAD Milbemycin Oxime… · 2
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Aortic stenosis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around ABNORMAL PANCREATIC SPECIFIC LIPASE

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ABNORMAL PANCREATIC S… · thi…11Aortic stenosis · near11Aqueous flare · near11Bile duct inflammation · near11Bowel torsion · near11Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI)

ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI): high death-coded share in the FDA AER plate

Signature read: 11 reports place ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) in the lower third of FDA AER volume (#2405 of 2,481). Report volume is lower-third scale: 11 named reports in the openFDA extract. Death-coded share is upper-third: 3 of 11 reports (27.3% of named reports). Nearest volume peer: Aortic stenosis (±0 reports). Lead species Dog (7). Lead co-reported drug Milbemycin Oxime + Spinosad (2).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 7
Cat 4

Breeds Most Affected

Domestic Shorthair 2
Sheepdog - Shetland 1
Terrier - Yorkshire 1
Shepherd Dog - Australian 1
Collie (unspecified) 1
Maltese 1
Rottweiler 1
Birman (Sacred Birman) 1
Domestic Longhair 1
Crossbred Canine/dog 1

Associated Drugs

Milbemycin Oxime + Spinosad 2
Cyclosporine 2
Semintra Telmisartan 4 Mg/Ml 2
Nitenpyram 1
Fluralaner Chew Tablets 1
Carprofen 1
Protamine Zinc Recombinant Human Insulin 1
Borrelia Burgdorferi Bacterin 1
Leptospira-Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1
Ketoconazole 1
Prednisone 1
Capromorelin 1
Maropitant 1
Gabapentin 1
Ranitidine 1
Grapiprant 1
Emodepside + Praziquantel 1
Selamectin 1
Enema 1
Insulin Injectable Vial 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (#2405 of 2,481 by report volume); death-coded 27.3%. PlainBreed reaction plate · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →