Reaction profile

The FDA adverse-event record for abnormal pancreatic specific lipase (pli)

11 FDA adverse-event reports reference abnormal pancreatic specific lipase (pli) (VeDDRA 93049). See the species, breeds, and drugs most associated with it below.

11
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
11
Total Reports
3
Deaths
27.3%
Death Rate

Species Most Affected

Dog 7
Cat 4

Breeds Most Affected

Domestic Shorthair 2
Sheepdog - Shetland 1
Shepherd Dog - Australian 1
Terrier - Yorkshire 1
Maltese 1
Collie (unspecified) 1
Rottweiler 1
Crossbred Canine/dog 1
Domestic Longhair 1
Birman (Sacred Birman) 1

Associated Drugs

Milbemycin Oxime + Spinosad 2
Cyclosporine 2
Semintra Telmisartan 4 Mg/Ml 2
Nitenpyram 1
Fluralaner Chew Tablets 1
Carprofen 1
Protamine Zinc Recombinant Human Insulin 1
Capromorelin 1
Maropitant 1
Gabapentin 1
Ranitidine 1
Borrelia Burgdorferi Bacterin 1
Leptospira-Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1
Ketoconazole 1
Prednisone 1
Grapiprant 1
Insulin Injectable Vial 1
Emodepside + Praziquantel 1
Selamectin 1
Enema 1

ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) Reaction Insights

11 reports name ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI); 3 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 93049.

By species: Dog (7 reports), Cat (4 reports). By breed: Domestic Shorthair (2), Sheepdog - Shetland (1), Shepherd Dog - Australian (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (2 reports), Cyclosporine (2 reports), Semintra Telmisartan 4 Mg/Ml (2 reports), Nitenpyram (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.