Reaction profile

The FDA adverse-event record for urinary tract bleeding

22 FDA adverse-event reports reference urinary tract bleeding (VeDDRA 1965). See the species, breeds, and drugs most associated with it below.

22
reports citing this reaction
50.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
22
Total Reports
11
Deaths
50.0%
Death Rate

Species Most Affected

Dog 18
Cat 3
Cattle 1

Breeds Most Affected

Pit Bull 3
Domestic Shorthair 3
Beagle 2
Siberian Husky 2
Schnauzer - Miniature 2
Rottweiler 1
Dog (unknown) 1
Mixed (Cattle) 1
Coonhound - Black and Tan 1
Sheepdog - Old English 1

Associated Drugs

Milbemycin Oxime + Spinosad 6
Diphenhydramine 3
Famotidine 3
Carprofen 2
Acepromazine 2
Tigilanol Tiglate 2
Prednisone 2
Lyme Vaccine 1
Deracoxib 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Firocoxib 227 Mg Chewable 1
Ivermectin + Pyrantel As Pamoate Salt 1
Afoxolaner 1
Robenacoxib 1
Ketamine 1
Xylazine 1
Fluid Therapy 1
Progesterone 1
Fluralaner Spot-On Solution 1
Spinosad 1

Urinary tract bleeding Reaction Insights

22 reports name Urinary tract bleeding; 11 recorded a death outcome (50.0% of reported events, not a population-level mortality rate). VeDDRA code: 1965.

By species: Dog (18 reports), Cat (3 reports), Cattle (1 reports). By breed: Pit Bull (3), Domestic Shorthair (3), Beagle (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (6 reports), Diphenhydramine (3 reports), Famotidine (3 reports), Carprofen (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.