Reaction profile

The FDA adverse-event record for toxic epidermal necrolysis

18 FDA adverse-event reports reference toxic epidermal necrolysis (VeDDRA 1848). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
27.8%
death-coded share
Dog
most-affected species
Cefovecin
most-associated drug
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18
Total Reports
5
Deaths
27.8%
Death Rate

Species Most Affected

Dog 13
Cat 4
Human 1

Breeds Most Affected

Domestic Shorthair 2
Dog (unknown) 2
Maltese 2
Hound (unspecified) 2
Maine Coon 1
Retriever - Labrador 1
Terrier - Boston 1
Shar Pei 1
Unknown 1
Terrier (unspecified) 1

Associated Drugs

Cefovecin 9
Maropitant Citrate 5
Meloxicam 3
Rabies Vaccine 2
Famotidine 2
Robenacoxib 2
Unspecified Clindamycin 2
Hydrocortisone Cream 2
Unspecified Prednisolone 2
Unspecified Omeprazole 2
Neomycin Sulfate;Tetracaine Hydrochloride 2
Cefpodoxime Proxetil 2
Pyrantel Pamoate;Sarolaner 2
Canine Parvovirus Strain Nl-35-D, P.35-D, 8-2-80;Canine Parainfluenza Virus, Str 2
Rabies Virus, Kv 2
Anti-Il31 Mab Mcs Lot #1283563 2
Prednisone 2
Ketoconazole 2
Onsior 2
Dental Sealant 2

Toxic epidermal necrolysis Reaction Insights

18 reports name Toxic epidermal necrolysis; 5 recorded a death outcome (27.8% of reported events, not a population-level mortality rate). VeDDRA code: 1848.

By species: Dog (13 reports), Cat (4 reports), Human (1 reports). By breed: Domestic Shorthair (2), Dog (unknown) (2), Maltese (2).

Most co-reported drugs: Cefovecin (9 reports), Maropitant Citrate (5 reports), Meloxicam (3 reports), Rabies Vaccine (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.