Reaction profile

The FDA adverse-event record for smell alteration

17 FDA adverse-event reports reference smell alteration (VeDDRA 1776). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
5.9%
death-coded share
Human
most-affected species
Copper Naphthenate
most-associated drug
Verify with FDA CVM →
17
Total Reports
1
Deaths
5.9%
Death Rate

Species Most Affected

Human 10
Dog 5
Cat 2

Breeds Most Affected

Unknown 10
Maine Coon 1
Terrier - Bull 1
Shepherd Dog - German 1
Collie - Border 1
Shepherd Dog - Australian 1
Mixed (Dog) 1
Domestic Shorthair 1

Associated Drugs

Copper Naphthenate 4
Imidacloprid + Moxidectin 3
Amoxicillin 2
Imidacloprid, Moxidectin 1
Mercaptobenzothiazole 1
Imidacloprid And Moxidectin 1
Chlorhexidine (3%) + Climbazole (0.5%) + Phytosphingosine (0.05%) 1
Clindamycin 1
Triamcinolone Acetonide (0.015%) 1
Milbemycin Oxime + Spinosad 1
Afoxolaner 1
Enrofloxacin 1
Trilostane 1
Bedinvetmab 1
Amantadine 1
Gabapentin 1
Vetoryl 1
Douxo S3 Calm Shampoo 1
Cosequin 1
Adams Flea Prevention 1

Smell alteration Reaction Insights

17 reports name Smell alteration; 1 recorded a death outcome (5.9% of reported events, not a population-level mortality rate). VeDDRA code: 1776.

By species: Human (10 reports), Dog (5 reports), Cat (2 reports). By breed: Unknown (10), Maine Coon (1), Terrier - Bull (1).

Most co-reported drugs: Copper Naphthenate (4 reports), Imidacloprid + Moxidectin (3 reports), Amoxicillin (2 reports), Imidacloprid, Moxidectin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.