Reaction profile

The FDA adverse-event record for retinal atrophy

Name: Retinal atrophy - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

18 FDA reports name retinal atrophy, a lower-volume reaction in the CVM extract (VeDDRA 462). Plate stamps and neighbourhood peers follow.

#2228 of 2,481
by report volume (all reactions): 18
reports citing this reaction: 5.6%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Retinal atrophy has 18 reports now versus 18 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Retinal atrophy changes

FDA AER · VeDDRA plate

Code 462 VOL-TRACE

VOL-TRACE · DEATH-PAR · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 18 reports
DEATH-PAR 5.6%
LOWER-Q #2228/2481
PHOTO-FINISH ALBUMIN/GLOBULIN RATI…
SPECIES-DOG Dog · 14
DRUG-LEAD Trilostane · 5
DESK-WIDE 13 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Retinal atrophy

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Retinal atrophy

Retinal atrophy: low death-coded share in the FDA AER plate

Signature read: 18 reports place Retinal atrophy in the lower third of FDA AER volume (#2228 of 2,481). Report volume is lower-third scale: 18 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 18 reports (5.6% of named reports). Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports). Lead species Dog (14). Lead co-reported drug Trilostane (5).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 14

Cat 4

Breeds Most Affected

Chihuahua 3

Shih Tzu 3

Cat (unknown) 2

Domestic Shorthair 1

Retriever - Golden 1

Schnauzer - Miniature 1

Maltese 1

Dachshund - Standard Long-haired 1

Terrier - Yorkshire 1

Retriever - Labrador 1

Associated Drugs

Trilostane 5

Spinosad 4

Oclacitinib Maleate 3

Enrofloxacin 2

Lufenuron + Milbemycin Oxime 2

Milbemycin Oxime + Spinosad 2

Ivermectin + Pyrantel Pamoate 1

Ivermectin 1

Dinotefuran/ Permethrin/ Pyriproxyfen 1

Selamectin 1

Moxidectin 1

Pyrantel Pamoate 1

Meloxicam 1

Cefpodoxime Proxetil 1

Doxycycline 1

Famotidine 1

Tramadol 1

Antihistamines 1

Fish Oil 1

Cyclosporine 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Retinal atrophy (#2228 of 2,481 by report volume); death-coded 5.6%. PlainBreed reaction plate · report volume stamp 18 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →