Reaction profile

The FDA adverse-event record for respiratory failure

46 FDA adverse-event reports reference respiratory failure (VeDDRA 1167). See the species, breeds, and drugs most associated with it below.

46
reports citing this reaction
89.1%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
46
Total Reports
41
Deaths
89.1%
Death Rate

Species Most Affected

Dog 32
Cat 12
Cattle 2

Breeds Most Affected

Domestic Shorthair 7
Shih Tzu 3
Holstein-Friesian also known as Holstein 2
Bulldog 2
Dog (unknown) 2
Chihuahua 2
Dachshund (unspecified) 2
Maltese 2
Terrier - Bull - American Pit 2
Cat (other) 2

Associated Drugs

Spinosad 5
Metronidazole 5
Moxidectin 5
Buprenorphine 5
Milbemycin Oxime + Spinosad 3
Pyrantel Pamoate 3
Meloxicam 3
Butorphanol 3
Melarsomine Dihydrochloride 3
Maropitant Citrate 3
Isoflurane 3
Metoclopramide 3
Maropitant 3
Dexamethasone 2
Doxycycline 2
Famotidine 2
Nitenpyram 2
Methylprednisolone Acetate 2
Atropine 2
Dexmedetomidine 2

Respiratory failure Reaction Insights

46 reports name Respiratory failure; 41 recorded a death outcome (89.1% of reported events, not a population-level mortality rate). VeDDRA code: 1167.

By species: Dog (32 reports), Cat (12 reports), Cattle (2 reports). By breed: Domestic Shorthair (7), Shih Tzu (3), Holstein-Friesian also known as Holstein (2).

Most co-reported drugs: Spinosad (5 reports), Metronidazole (5 reports), Moxidectin (5 reports), Buprenorphine (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.