Reaction profile

The FDA adverse-event record for entropion

49 FDA reports name entropion, a lower-volume reaction in the CVM extract (VeDDRA 425). Plate stamps and neighbourhood peers follow.

#1742 of 2,481
by report volume (all reactions)
49
reports citing this reaction
4.1%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Entropion has 49 reports now versus 48 in that prior snapshot: 1 more (2.1%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Entropion changes

FDA AER · VeDDRA plate

Code 425 VOL-TRACE

VOL-TRACE · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 49 reports
  • DEATH-LOW 4.1%
  • MID-PACK #1742/2481
  • PHOTO-FINISH Hepatic fibrosis
  • SPECIES-DOG Dog · 48
  • DRUG-LEAD Milbemycin Oxime… · 21
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hepatic fibrosis (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Entropion

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Entropion · this reaction49Hepatic fibrosis · near49INEFFECTIVE, STRONGYL… · near49Nerve damage NOS · near49Pinnal ulcer · near49Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Entropion

Entropion: low death-coded share in the FDA AER plate

Signature read: 2 death-coded reports is a thin tail count for Entropion in the CVM extract. Report volume is lower-third scale: 49 named reports in the openFDA extract. Death-coded share is lower-third: 2 of 49 reports (4.1% of named reports). Nearest volume peer: Hepatic fibrosis (±0 reports). Lead species Dog (48). Lead co-reported drug Milbemycin Oxime + Spinosad (21).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 48
Cat 1

Breeds Most Affected

Retriever - Labrador 11
Bulldog 6
Rottweiler 3
Retriever - Golden 3
Shar Pei 2
Boxer (German Boxer) 2
Saint Bernard Dog 2
Bloodhound 2
Shih Tzu 2
Poodle - Standard 2

Associated Drugs

Milbemycin Oxime + Spinosad 21
Milbemycin Oxime + Praziquantel 9
Oclacitinib Maleate 8
Afoxolaner 4
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 4
Deracoxib 3
Fluralaner 3
Imidacloprid + Moxidectin 3
Prednisone 3
Pilocarpine 3
Spinosad 2
Fluralaner Chew Tablets 2
Cefpodoxime Proxetil 2
Ivermectin + Pyrantel As Pamoate Salt 2
Dexamethasone 2
Maropitant Citrate 2
Ketoconazole,Hydrocortisone 2
Meclizine 2
Eye Lube 2
Fluid Therapy (Unknown) 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Entropion (#1742 of 2,481 by report volume); death-coded 4.1%. PlainBreed reaction plate · death-coded report count stamp 2 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →