Reaction profile

The FDA adverse-event record for entropion

47 FDA adverse-event reports reference entropion (VeDDRA 425). See the species, breeds, and drugs most associated with it below.

47
reports citing this reaction
4.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
47
Total Reports
2
Deaths
4.3%
Death Rate

Species Most Affected

Dog 46
Cat 1

Breeds Most Affected

Retriever - Labrador 11
Bulldog 6
Rottweiler 3
Shar Pei 2
Boxer (German Boxer) 2
Bloodhound 2
Saint Bernard Dog 2
Shih Tzu 2
Retriever - Golden 2
Poodle - Miniature 2

Associated Drugs

Milbemycin Oxime + Spinosad 21
Milbemycin Oxime + Praziquantel 9
Oclacitinib Maleate 8
Afoxolaner 4
Deracoxib 3
Fluralaner 3
Imidacloprid + Moxidectin 3
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 3
Pilocarpine 3
Spinosad 2
Fluralaner Chew Tablets 2
Cefpodoxime Proxetil 2
Ivermectin + Pyrantel As Pamoate Salt 2
Prednisone 2
Dexamethasone 2
Maropitant Citrate 2
Ketoconazole,Hydrocortisone 2
Meclizine 2
Eye Lube 2
Fluid Therapy (Unknown) 2

Entropion Reaction Insights

47 reports name Entropion; 2 recorded a death outcome (4.3% of reported events, not a population-level mortality rate). VeDDRA code: 425.

By species: Dog (46 reports), Cat (1 reports). By breed: Retriever - Labrador (11), Bulldog (6), Rottweiler (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (21 reports), Milbemycin Oxime + Praziquantel (9 reports), Oclacitinib Maleate (8 reports), Afoxolaner (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.