Reaction profile

The FDA adverse-event record for poor peripheral circulation

45 FDA adverse-event reports reference poor peripheral circulation (VeDDRA 1702). See the species, breeds, and drugs most associated with it below.

45
reports citing this reaction
77.8%
death-coded share
Dog
most-affected species
Deracoxib
most-associated drug
Verify with FDA CVM →
45
Total Reports
35
Deaths
77.8%
Death Rate

Species Most Affected

Dog 29
Cat 10
Horse 4
Human 2

Breeds Most Affected

Retriever - Labrador 6
Domestic Shorthair 5
Unknown 3
Terrier - Yorkshire 2
Siamese 2
Crossbred Canine/dog 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Poodle - Standard 2
Pug 2
Thoroughbred 2

Associated Drugs

Deracoxib 11
Milbemycin Oxime + Spinosad 6
Carprofen 5
Robenacoxib 3
Trilostane 3
Spinosad 3
Tramadol 3
Polysulfated Glycosaminoglycan 3
Desoxycorticosterone Pivalate 2
Fipronil 2
Buprenorphine 2
Cyclosporine A 2
Lufenuron + Milbemycin Oxime 2
Mirtazapine 1
Maropitant Injection 1
Maropitant Tablets 1
Alprazolam 1
Ivermectin/Pyrantel 1
Prednisone 1
Melarsomine Dihydrochloride Injection 1

Poor peripheral circulation Reaction Insights

45 reports name Poor peripheral circulation; 35 recorded a death outcome (77.8% of reported events, not a population-level mortality rate). VeDDRA code: 1702.

By species: Dog (29 reports), Cat (10 reports), Horse (4 reports). By breed: Retriever - Labrador (6), Domestic Shorthair (5), Unknown (3).

Most co-reported drugs: Deracoxib (11 reports), Milbemycin Oxime + Spinosad (6 reports), Carprofen (5 reports), Robenacoxib (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.