Poor peripheral circulation

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VeDDRA Code: 1702

45 adverse event reports referencing this reaction

45
Total Reports
35
Deaths
7780.0%
Death Rate

Species Most Affected

Dog 29
Cat 10
Horse 4
Human 2

Breeds Most Affected

Retriever - Labrador 6
Domestic Shorthair 5
Unknown 3
Terrier - Yorkshire 2
Siamese 2
Crossbred Canine/dog 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Poodle - Standard 2
Pug 2
Thoroughbred 2

Associated Drugs

Deracoxib 11
Milbemycin Oxime + Spinosad 6
Carprofen 5
Robenacoxib 3
Trilostane 3
Spinosad 3
Tramadol 3
Polysulfated Glycosaminoglycan 3
Desoxycorticosterone Pivalate 2
Fipronil 2
Buprenorphine 2
Cyclosporine A 2
Lufenuron + Milbemycin Oxime 2
Mirtazapine 1
Maropitant Injection 1
Maropitant Tablets 1
Alprazolam 1
Ivermectin/Pyrantel 1
Prednisone 1
Melarsomine Dihydrochloride Injection 1

Data Summary

Metric Value
Total reports referencing reaction 45
Reports with fatal outcome 35
Case-fatality rate (reported events) 7780.0%
Species observed 4
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1702.

Poor peripheral circulation Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 45 adverse event reports that reference Poor peripheral circulation as a reaction term, including 35 reports with a death outcome — a 7780.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1702, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Poor peripheral circulation appears most frequently in reports for Dog (29 reports), Cat (10 reports), Horse (4 reports) — with Dog dominating at 29 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (6), Domestic Shorthair (5), Unknown (3). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Poor peripheral circulation are Deracoxib (11 reports), Milbemycin Oxime + Spinosad (6 reports), Carprofen (5 reports), Robenacoxib (3 reports), with Deracoxib appearing alongside this reaction in 11 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial