Reaction profile

The FDA adverse-event record for perineal fistula

38 FDA adverse-event reports reference perineal fistula (VeDDRA 255). See the species, breeds, and drugs most associated with it below.

38
reports citing this reaction
7.9%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
38
Total Reports
3
Deaths
7.9%
Death Rate

Species Most Affected

Dog 38

Breeds Most Affected

Shepherd Dog - German 17
Retriever - Labrador 5
Shih Tzu 2
Terrier - Bull - American Pit 2
Chow Chow 1
Catahoula Leopard Dog 1
Corgi - Welsh Cardigan 1
Beagle 1
Collie (unspecified) 1
Spaniel - Springer English 1

Associated Drugs

Oclacitinib Maleate 16
Cyclosporine 8
Trilostane 3
Ketoconazole 3
Cefpodoxime Proxetil 2
Tylosin Tartrate 2
Trimeprazine Tartrate + Prednisolone 2
Lokivetmab Injectable Solution 2
Tacrolimus Ointment 0.03% 2
Bedinvetmab 2
Firocoxib 227 Mg 1
Cyclosporine A 1
Firocoxib 1
Glucosamine/Chondroitin Sulfate 1
Distemper Vaccination 1
Gentamicin Sulfate / Mometasone Furoate Monohydrate / Clotrimazole Topical Ear Solution 1
Milbemycin Oxime + Spinosad 1
Meloxicam 1
Firocoxib 227 Mg Chewable 1
Prednisolone; Trimeprazine Tartrate 1

Perineal fistula Reaction Insights

38 reports name Perineal fistula; 3 recorded a death outcome (7.9% of reported events, not a population-level mortality rate). VeDDRA code: 255.

By species: Dog (38 reports). By breed: Shepherd Dog - German (17), Retriever - Labrador (5), Shih Tzu (2).

Most co-reported drugs: Oclacitinib Maleate (16 reports), Cyclosporine (8 reports), Trilostane (3 reports), Ketoconazole (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.