Reaction profile

The FDA adverse-event record for application site numbness

42 FDA adverse-event reports reference application site numbness (VeDDRA 2192). See the species, breeds, and drugs most associated with it below.

42
reports citing this reaction
0.0%
death-coded share
Human
most-affected species
Fluralaner Spot-On Solution
most-associated drug
Verify with FDA CVM →
42
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Human 39
Horse 1
Dog 1
Cat 1

Breeds Most Affected

Unknown 39
Horse (unknown) 1
Terrier - Jack Russell 1
Cat (unknown) 1

Associated Drugs

Fluralaner Spot-On Solution 9
Imidacloprid + Moxidectin 8
Fluralaner/Moxidectin Spot-On 7
Selamectin 5
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 1
Ivermectin + Pyrantel As Pamoate Salt 1
Soap 1
Moxidectin 1
Altrenogest Oily Solution 1
Diphenhydramine 1
Hydrocortisone Cream 1
Pentobarbital/Phenytoin Inj 1
Unspecified Liquid Dish Soap 1
Unspecified Hand Soap 1
Flunixin Meglumine Injectable 1
Capromorelin 1
Mirtazapine 1
Emodepside + Praziquantel 1
Eprinomectin + Esafoxolaner + Praziquantel 1
Eprinomectin + Praziquantel 1

Application site numbness Reaction Insights

42 reports name Application site numbness; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2192.

By species: Human (39 reports), Horse (1 reports), Dog (1 reports). By breed: Unknown (39), Horse (unknown) (1), Terrier - Jack Russell (1).

Most co-reported drugs: Fluralaner Spot-On Solution (9 reports), Imidacloprid + Moxidectin (8 reports), Fluralaner/Moxidectin Spot-On (7 reports), Selamectin (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.