Reaction profile

The FDA adverse-event record for pericardial haemorrhage

37 FDA adverse-event reports reference pericardial haemorrhage (VeDDRA 238). See the species, breeds, and drugs most associated with it below.

37
reports citing this reaction
94.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
37
Total Reports
35
Deaths
94.6%
Death Rate

Species Most Affected

Dog 27
Cattle 4
Cat 3
Horse 1
Pig 1
Snake 1

Breeds Most Affected

Retriever - Labrador 5
Shepherd Dog - Australian 3
Crossbred Canine/dog 3
Shih Tzu 2
Shepherd Dog - German 2
Terrier - Yorkshire 2
Domestic Shorthair 2
Retriever (unspecified) 2
Bulldog 2
Pointer (unspecified) 1

Associated Drugs

Milbemycin Oxime + Spinosad 11
Spinosad 6
Ivermectin 4
Moxidectin 4
Monensin Sodium 3
Fipronil 2
Glucosamine + Chondroitin 2
Milbemycin Oxime + Lufenuron 2
Milbemycin Oxime 2
Afoxolaner 2
Oclacitinib Maleate 2
Fluralaner Chew Tablets 2
Robenacoxib 2
Bedinvetmab 2
Carprofen 2
Cefovecin Sodium 1
Triamcinolone Acetonide 1
Medicated Shampoo (Unknown) 1
Dexdomitor/Torbugesic Combination 1
Levothyroxine Sodium 1

Pericardial haemorrhage Reaction Insights

37 reports name Pericardial haemorrhage; 35 recorded a death outcome (94.6% of reported events, not a population-level mortality rate). VeDDRA code: 238.

By species: Dog (27 reports), Cattle (4 reports), Cat (3 reports). By breed: Retriever - Labrador (5), Shepherd Dog - Australian (3), Crossbred Canine/dog (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (11 reports), Spinosad (6 reports), Ivermectin (4 reports), Moxidectin (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.