Reaction profile

The FDA adverse-event record for pemphigus

38 FDA adverse-event reports reference pemphigus (VeDDRA 509). See the species, breeds, and drugs most associated with it below.

38
reports citing this reaction
10.5%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
38
Total Reports
4
Deaths
10.5%
Death Rate

Species Most Affected

Dog 33
Cat 5

Breeds Most Affected

Dog (unknown) 4
Crossbred Canine/dog 2
Shepherd Dog - German 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Domestic Shorthair 2
Retriever - Labrador 2
Schnauzer (unspecified) 1
Spaniel - Cocker American 1
Dog (other) 1
Poodle - Standard 1

Associated Drugs

Oclacitinib Maleate 6
Cephalexin 4
Selamectin 4
Ivermectin + Pyrantel As Pamoate Salt 4
Carprofen 4
Enrofloxacin 3
Prednisone 3
Milbemycin Oxime + Spinosad 3
Moxidectin 3
Anti-Il31 Mab Mcs Lot #1283563 3
Cefovecin 3
Spinosad 2
Benzoyl Peroxide 2
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 2
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 2
Fish Oil 2
Gabapentin 2
Sarolaner 2
Frunevetmab 2
Frontline 1

Pemphigus Reaction Insights

38 reports name Pemphigus; 4 recorded a death outcome (10.5% of reported events, not a population-level mortality rate). VeDDRA code: 509.

By species: Dog (33 reports), Cat (5 reports). By breed: Dog (unknown) (4), Crossbred Canine/dog (2), Shepherd Dog - German (2).

Most co-reported drugs: Oclacitinib Maleate (6 reports), Cephalexin (4 reports), Selamectin (4 reports), Ivermectin + Pyrantel As Pamoate Salt (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.