Reaction profile

The FDA adverse-event record for hydrocephalus

38 FDA adverse-event reports reference hydrocephalus (VeDDRA 641). See the species, breeds, and drugs most associated with it below.

38
reports citing this reaction
71.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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38
Total Reports
27
Deaths
71.1%
Death Rate

Species Most Affected

Dog 37
Horse 1

Breeds Most Affected

Chihuahua 5
Boxer (German Boxer) 4
Retriever - Golden 3
Terrier - Bull - American Pit 3
Bulldog - French 3
Terrier - Yorkshire 2
Shepherd Dog - Australian 2
Shih Tzu 1
Spaniel - King Charles Cavalier 1
Pug 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Pyrantel Pamoate;Sarolaner 5
Afoxolaner 4
Maropitant Citrate 4
Fluralaner 13.64% 12-Week Chew 3
Carprofen 2
Spinosad 2
Fluralaner Chew Tablets 2
Acepromazine Maleate 2
Moxidectin 2
Diazepam 2
Sarolaner 2
Isoflurane 1
Milbemycin Oxime + Lufenuron 1
Gentamicin Sulfate + Betamethasone Valerate + Clotrimatzole 1
Selamectin 1
Polysulfated Glycosaminoglycan 1
Ivermectin + Pyrantel As Pamoate Salt 1
Ivermectin + Pyrantel 1
Milbemycin Oxime, Lufenuron 1

Hydrocephalus Reaction Insights

38 reports name Hydrocephalus; 27 recorded a death outcome (71.1% of reported events, not a population-level mortality rate). VeDDRA code: 641.

By species: Dog (37 reports), Horse (1 reports). By breed: Chihuahua (5), Boxer (German Boxer) (4), Retriever - Golden (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Pyrantel Pamoate;Sarolaner (5 reports), Afoxolaner (4 reports), Maropitant Citrate (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.