Reaction profile

The FDA adverse-event record for panosteitis

11 FDA adverse-event reports reference panosteitis (VeDDRA 1948). See the species, breeds, and drugs most associated with it below.

11
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
11
Total Reports
3
Deaths
27.3%
Death Rate

Species Most Affected

Dog 11

Breeds Most Affected

Shepherd Dog - German 4
Retriever - Labrador 2
Collie - Border 1
Mountain Dog - Bernese 1
Bulldog - American 1
Pointing Dog - German Wire-haired 1
Shepherd (unspecified) 1

Associated Drugs

Milbemycin Oxime + Spinosad 10
Afoxolaner 3
Milbemycin Oxime + Praziquantel 3
Ivermectin + Pyrantel As Pamoate Salt 2
Deracoxib 2
Fipronil 10%/S Methoprene 9% Spot On 1
Ivermectin 1
Carprofen 1
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 1
Gabapentin 1
Antibiotic 1
Sucralfate 1
Tramadol 1
Prednisone 1
Buprenorphine 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Milbemycin Oxime 1
Borrelia Burgdorferi Bacterin 1
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1
Flumethrin + Imidacloprid 1

Panosteitis Reaction Insights

11 reports name Panosteitis; 3 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 1948.

By species: Dog (11 reports). By breed: Shepherd Dog - German (4), Retriever - Labrador (2), Collie - Border (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (10 reports), Afoxolaner (3 reports), Milbemycin Oxime + Praziquantel (3 reports), Ivermectin + Pyrantel As Pamoate Salt (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.