Reaction profile

The FDA adverse-event record for panosteitis

Name: Panosteitis - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

11 FDA reports name panosteitis, a lower-volume reaction in the CVM extract (VeDDRA 1948). Plate stamps and neighbourhood peers follow.

#2437 of 2,481
by report volume (all reactions): 11
reports citing this reaction: 27.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Panosteitis has 11 reports now versus 11 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Panosteitis changes

FDA AER · VeDDRA plate

Code 1948 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-MID · BOOK-FULL

VOL-TRACE 11 reports
DEATH-HOT 27.3%
BOTTOM-DECILE #2437/2481
PHOTO-FINISH ABNORMAL PANCREATIC S…
SPECIES-DOG Dog · 11
DRUG-LEAD Milbemycin Oxime… · 10
DESK-MID 7 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Panosteitis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Panosteitis

Panosteitis: high death-coded share in the FDA AER plate

Signature read: 11 reports place Panosteitis in the lower third of FDA AER volume (#2437 of 2,481). Report volume is lower-third scale: 11 named reports in the openFDA extract. Death-coded share is upper-third: 3 of 11 reports (27.3% of named reports). Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports). Lead species Dog (11). Lead co-reported drug Milbemycin Oxime + Spinosad (10).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 11

Breeds Most Affected

Shepherd Dog - German 4

Retriever - Labrador 2

Collie - Border 1

Mountain Dog - Bernese 1

Bulldog - American 1

Pointing Dog - German Wire-haired 1

Shepherd (unspecified) 1

Associated Drugs

Milbemycin Oxime + Spinosad 10

Afoxolaner 3

Milbemycin Oxime + Praziquantel 3

Ivermectin + Pyrantel As Pamoate Salt 2

Deracoxib 2

Fipronil 10%/S Methoprene 9% Spot On 1

Ivermectin 1

Carprofen 1

Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 1

Gabapentin 1

Antibiotic 1

Sucralfate 1

Tramadol 1

Prednisone 1

Buprenorphine 1

Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1

Milbemycin Oxime 1

Borrelia Burgdorferi Bacterin 1

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1

Flumethrin + Imidacloprid 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Panosteitis (#2437 of 2,481 by report volume); death-coded 27.3%. PlainBreed reaction plate · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →