Other metabolic disorder

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VeDDRA Code: 1668

34 adverse event reports referencing this reaction

34
Total Reports
9
Deaths
2650.0%
Death Rate

Species Most Affected

Dog 16
Cat 7
Horse 4
Goat 3
Cattle 2
Turkey 2

Breeds Most Affected

Retriever - Labrador 4
Domestic Shorthair 4
Boer 3
Turkey (unknown) 2
Unknown 1
Spaniel - King Charles Cavalier 1
Dachshund - Standard Smooth-haired 1
Holstein-Friesian also known as Holstein 1
Shepherd Dog - German 1
Doberman Pinscher 1

Associated Drugs

Monensin Sodium 6
Milbemycin Oxime + Spinosad 4
Ivermectin + Pyrantel As Pamoate Salt 4
Bexagliflozin 4
Afoxolaner 2
Trenbolone Acet/Estrad Sr Imp 2
Prednisone 2
Pergolide Mesylate 2
Metronidazole 2
Prescription Diet 2
Pyrantel 1
Pain Meds (Unknown) 1
Trilostane 1
Tramadol 1
Sometribove 1
Afoxolaner 136 Mg Chewable Tablets 1
Imidacloprid/Moxidectin 1
Milbemycin Oxime/Praziquantel 1
Deracoxib 1
Fatty Acid/Fish Oil Supplement 1

Data Summary

Metric Value
Total reports referencing reaction 34
Reports with fatal outcome 9
Case-fatality rate (reported events) 2650.0%
Species observed 6
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1668.

Other metabolic disorder Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 34 adverse event reports that reference Other metabolic disorder as a reaction term, including 9 reports with a death outcome — a 2650.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1668, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Other metabolic disorder appears most frequently in reports for Dog (16 reports), Cat (7 reports), Horse (4 reports) — with Dog dominating at 16 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (4), Domestic Shorthair (4), Boer (3). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Other metabolic disorder are Monensin Sodium (6 reports), Milbemycin Oxime + Spinosad (4 reports), Ivermectin + Pyrantel As Pamoate Salt (4 reports), Bexagliflozin (4 reports), with Monensin Sodium appearing alongside this reaction in 6 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial