Reaction profile

The FDA adverse-event record for carbon dioxide low, blood

35 FDA reports name carbon dioxide low, blood, a lower-volume reaction in the CVM extract (VeDDRA 99231). Plate stamps and neighbourhood peers follow.

#1917 of 2,481
by report volume (all reactions)
35
reports citing this reaction
42.9%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. CARBON DIOXIDE LOW, BLOOD has 35 reports now versus 33 in that prior snapshot: 2 more (6.1%).

Report change
+2
Death-coded reports
+1
Death-coded share
+0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to CARBON DIOXIDE LOW, BLOOD changes

FDA AER · VeDDRA plate

Code 99231 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 35 reports
  • DEATH-HOT 42.9%
  • LOWER-Q #1917/2481
  • PHOTO-FINISH Cerebral oedema
  • SPECIES-DOG Dog · 26
  • DRUG-LEAD Carprofen · 6
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cerebral oedema (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around CARBON DIOXIDE LOW, BLOOD

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348CARBON DIOXIDE LOW, B… · thi…35Cerebral oedema · near35Comedo/blackhead · near35Gastric torsion · near35Injection site joint… · near35Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around CARBON DIOXIDE LOW, BLOOD

CARBON DIOXIDE LOW, BLOOD: high death-coded share in the FDA AER plate

Signature read: CARBON DIOXIDE LOW, BLOOD's 42.9% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 35 named reports in the openFDA extract. Death-coded share is upper-third: 15 of 35 reports (42.9% of named reports). Nearest volume peer: Cerebral oedema (±0 reports). Lead species Dog (26). Lead co-reported drug Carprofen (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 26
Cat 9

Breeds Most Affected

Domestic (unspecified) 7
Terrier - Yorkshire 3
Crossbred Canine/dog 2
Domestic Shorthair 2
Spaniel - Springer (unspecified) 1
Rottweiler 1
Shepherd Dog - German 1
Schnauzer (unspecified) 1
Mixed (Dog) 1
Maltese 1

Associated Drugs

Carprofen 6
Meloxicam 5
Polysulfated Glycosaminoglycan 4
Milbemycin Oxime + Spinosad 4
Diphenhydramine 4
Spinosad 3
Maropitant 3
Enrofloxacin 3
Ivermectin + Pyrantel As Pamoate Salt 3
Metoclopramide 2
Afoxolaner 2
Epinephrine 2
Fluids 2
Fuzapladib Sodium 2
Firocoxib 1
Cefovecin Sodium 1
Sulfadiazine, Trimethoprim 1
Ampicillin Trihydrate 1
Nitenpyram 1
Maropitant Citrate 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for CARBON DIOXIDE LOW, BLOOD (#1917 of 2,481 by report volume); death-coded 42.9%. PlainBreed reaction plate · death-coded share stamp 42.9% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →