Reaction profile

The FDA adverse-event record for nt - necrotic hepatitis

18 FDA adverse-event reports reference nt - necrotic hepatitis (VeDDRA 2326). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
100.0%
death-coded share
Dog
most-affected species
Meloxicam
most-associated drug
Verify with FDA CVM →
18
Total Reports
18
Deaths
100.0%
Death Rate

Species Most Affected

Dog 14
Cat 2
Horse 1
Tiger 1

Breeds Most Affected

Crossbred Canine/dog 3
Boxer (German Boxer) 3
Beagle 2
Dachshund (unspecified) 2
Domestic Shorthair 2
Shih Tzu 1
Thoroughbred 1
Retriever - Labrador 1
Retriever - Golden 1
Shepherd Dog - German 1

Associated Drugs

Meloxicam 3
Fluralaner Chew Tablets 2
Afoxolaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Carprofen 2
Cefovecin Sodium 2
Maropitant Citrate 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 1
Bordetella Bronchiseptica, Strain 78-9159, Kb 1
Borrelia Burgdorferi Strain Ips 930-34-081596; Borrelia Burgdorferi Strain B-31 1
Doxycycline 1
Clopidogrel Bisulfate 1
Anesthesia 1
Milbemycin Oxime + Spinosad 1
Clavamox 1
Pergolide Mesylate 1
Apoquel 1
Hydroxyzine 1
Ampicillin Trihydrate 1

NT - necrotic hepatitis Reaction Insights

18 reports name NT - necrotic hepatitis; 18 recorded a death outcome (100.0% of reported events, not a population-level mortality rate). VeDDRA code: 2326.

By species: Dog (14 reports), Cat (2 reports), Horse (1 reports). By breed: Crossbred Canine/dog (3), Boxer (German Boxer) (3), Beagle (2).

Most co-reported drugs: Meloxicam (3 reports), Fluralaner Chew Tablets (2 reports), Afoxolaner (2 reports), Ivermectin + Pyrantel As Pamoate Salt (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.