Reaction profile

The FDA adverse-event record for nt - necrotic hepatitis

18 FDA reports name nt - necrotic hepatitis, a lower-volume reaction in the CVM extract (VeDDRA 2326). Plate stamps and neighbourhood peers follow.

#2221 of 2,481
by report volume (all reactions)
18
reports citing this reaction
100.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. NT - necrotic hepatitis has 18 reports now versus 18 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to NT - necrotic hepatitis changes

FDA AER · VeDDRA plate

Code 2326 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 18 reports
  • DEATH-HOT 100.0%
  • LOWER-Q #2221/2481
  • PHOTO-FINISH ALBUMIN/GLOBULIN RATI…
  • SPECIES-DOG Dog · 14
  • DRUG-LEAD Meloxicam · 3
  • DESK-WIDE 11 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around NT - necrotic hepatitis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ALBUMIN/GLOBULIN RATI… · near18Application site skin… · near18Bone marrow hypoplasia · near18Cognitive disturbance · near18NT - necrotic hepatit… · thi…18Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around NT - necrotic hepatitis

NT - necrotic hepatitis: high death-coded share in the FDA AER plate

Signature read: NT - necrotic hepatitis's 100.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 18 named reports in the openFDA extract. Death-coded share is upper-third: 18 of 18 reports (100.0% of named reports). Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports). Lead species Dog (14). Lead co-reported drug Meloxicam (3).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 14
Cat 2
Horse 1
Tiger 1

Breeds Most Affected

Boxer (German Boxer) 3
Crossbred Canine/dog 3
Beagle 2
Dachshund (unspecified) 2
Domestic Shorthair 2
Shih Tzu 1
Thoroughbred 1
Retriever - Labrador 1
Retriever - Golden 1
Shepherd Dog - German 1

Associated Drugs

Meloxicam 3
Fluralaner Chew Tablets 2
Afoxolaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Carprofen 2
Cefovecin Sodium 2
Maropitant Citrate 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 1
Bordetella Bronchiseptica, Strain 78-9159, Kb 1
Borrelia Burgdorferi Strain Ips 930-34-081596; Borrelia Burgdorferi Strain B-31 1
Doxycycline 1
Clopidogrel Bisulfate 1
Anesthesia 1
Milbemycin Oxime + Spinosad 1
Clavamox 1
Pergolide Mesylate 1
Apoquel 1
Hydroxyzine 1
Ampicillin Trihydrate 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for NT - necrotic hepatitis (#2221 of 2,481 by report volume); death-coded 100.0%. PlainBreed reaction plate · death-coded share stamp 100.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →