Reaction profile

The FDA adverse-event record for neck writhing

45 FDA reports name neck writhing, a lower-volume reaction in the CVM extract (VeDDRA 2546). Plate stamps and neighbourhood peers follow.

#1796 of 2,481
by report volume (all reactions)
45
reports citing this reaction
15.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Neck writhing has 45 reports now versus 45 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Neck writhing changes

FDA AER · VeDDRA plate

Code 2546 VOL-TRACE

VOL-TRACE · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 45 reports
  • DEATH-ELEV 15.6%
  • MID-PACK #1796/2481
  • PHOTO-FINISH Application site disc…
  • SPECIES-DOG Dog · 34
  • DRUG-LEAD Milbemycin Oxime… · 10
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site discharge NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Neck writhing

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site disc… · near45Buccal irritation · near45Chest tightness · near45Flaccid paralysis · near45Neck writhing · this reaction45Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Neck writhing

What the FDA AER plate says about Neck writhing

Signature read: 45 reports place Neck writhing in the lower third of FDA AER volume (#1796 of 2,481). Report volume is lower-third scale: 45 named reports in the openFDA extract. 7 of 45 reports were death-coded (15.6% of named reports, not a population mortality rate). Nearest volume peer: Application site discharge NOS (±0 reports). Lead species Dog (34). Lead co-reported drug Milbemycin Oxime + Spinosad (10).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 34
Horse 4
Cat 3
Cattle 3
Alpaca 1

Breeds Most Affected

Chihuahua 6
Domestic Shorthair 3
Crossbred Canine/dog 3
Terrier - West Highland White 2
Warmblood (unspecified) 2
Retriever - Labrador 2
Crossbred Bovine/Cattle 2
Bulldog 2
Corgi - Welsh Cardigan 2
Retriever - Golden 2

Associated Drugs

Milbemycin Oxime + Spinosad 10
Afoxolaner 8
Ceftiofur Crystalline Free Acid 3
Fluralaner 13.64% 12-Week Chew 2
Pyrantel Pamoate;Sarolaner 2
Melarsomine Dihydrochloride 2
Prednisone 2
Milbemycin/Lufenuron/Pzq Chew 2
Ivermectin + Pyrantel As Pamoate Salt 2
Sarolaner 1
Dexamethasone 1
Diazepam 1
Clodronate Disodium 1
Firocoxib 1
Oclacitinib 1
Mirtazapine 1
Amoxicillin 1
Robenacoxib 1
Alprazolam 1
Butorphanol Tartrate 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Neck writhing (#1796 of 2,481 by report volume); death-coded 15.6%. PlainBreed reaction plate · report volume stamp 45 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →