Reaction profile

The FDA adverse-event record for multiple organ haemorrhage

36 FDA adverse-event reports reference multiple organ haemorrhage (VeDDRA 2097). See the species, breeds, and drugs most associated with it below.

36
reports citing this reaction
100.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
36
Total Reports
36
Deaths
100.0%
Death Rate

Species Most Affected

Dog 29
Cat 5
Cattle 1
Horse 1

Breeds Most Affected

Shepherd Dog - German 6
Retriever - Labrador 4
Domestic Shorthair 4
Shih Tzu 2
Dachshund (unspecified) 1
Schnauzer (unspecified) 1
Collie - Border 1
Siberian Husky 1
Crossbred Canine/dog 1
Terrier - Jack Russell 1

Associated Drugs

Milbemycin Oxime + Spinosad 20
Maropitant Citrate 3
Carprofen 2
Ivermectin 2
Doxycycline 2
Prednisone 2
Rabies Vaccine 2
Dexmedetomidine 2
Butorphanol 2
Ketamine 2
Lyme Vaccine 2
Spinosad 1
Heartworm Prevention (Unknown) 1
Hydroxyzine 1
Ivermectin 68Mcg, Pyrantel Pamoate 57Mg, Praziquantel 57Mg 1
Deracoxib 1
Dexmedetomidine, Butorphanol 1
Lufenuron + Milbemycin Oxime 1
Clotrimazole, Gentamicin, Betamethasone 1
Glucosamine Supplement 1

Multiple organ haemorrhage Reaction Insights

36 reports name Multiple organ haemorrhage; 36 recorded a death outcome (100.0% of reported events, not a population-level mortality rate). VeDDRA code: 2097.

By species: Dog (29 reports), Cat (5 reports), Cattle (1 reports). By breed: Shepherd Dog - German (6), Retriever - Labrador (4), Domestic Shorthair (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (20 reports), Maropitant Citrate (3 reports), Carprofen (2 reports), Ivermectin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.