Reaction profile

The FDA adverse-event record for clenched jaw

28 FDA adverse-event reports reference clenched jaw (VeDDRA 3101). See the species, breeds, and drugs most associated with it below.

28
reports citing this reaction
17.9%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
28
Total Reports
5
Deaths
17.9%
Death Rate

Species Most Affected

Dog 25
Cat 2
Pig 1

Breeds Most Affected

Dog (unknown) 3
Hound (unspecified) 2
Crossbred Canine/dog 2
Domestic Shorthair 2
Terrier - Rat 1
Poodle - Toy 1
Shepherd Dog - German 1
Schipperke 1
Spitz - German Pomeranian 1
Setter (unspecified) 1

Associated Drugs

Pyrantel Pamoate;Sarolaner 4
Bedinvetmab 4
Carprofen 4
Mirtazapine 3
Ivermectin + Pyrantel As Pamoate Salt 2
Milbemycin Oxime + Praziquantel 2
Entyce 2
Oclacitinib Maleate 2
Ursodiol 2
Tramadol 2
Maropitant Citrate 2
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 2
Subcutaneous Fluids 2
Diphenhydramine 2
Afoxolaner 9.375Mg / Moxidectin 45Mcg / Pyrantel 18.75Mg Chewable Tablet 2
Propofol 2
Milbemycin Oxime + Spinosad 1
Flea Product (Unknown) 1
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 1
Imidacloprid + Moxidectin 1

Clenched jaw Reaction Insights

28 reports name Clenched jaw; 5 recorded a death outcome (17.9% of reported events, not a population-level mortality rate). VeDDRA code: 3101.

By species: Dog (25 reports), Cat (2 reports), Pig (1 reports). By breed: Dog (unknown) (3), Hound (unspecified) (2), Crossbred Canine/dog (2).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (4 reports), Bedinvetmab (4 reports), Carprofen (4 reports), Mirtazapine (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.