Reaction profile

The FDA adverse-event record for mixed product

227 FDA adverse-event reports reference mixed product (VeDDRA 99956). See the species, breeds, and drugs most associated with it below.

227
reports citing this reaction
0.0%
death-coded share
Unknown
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
227
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Unknown 221
Dog 4
Human 1
Cat 1

Breeds Most Affected

Unknown 222
Terrier - Yorkshire 1
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 1
Schnauzer - Miniature 1
Schnauzer (unspecified) 1
Domestic Shorthair 1

Associated Drugs

Afoxolaner 26
Pimobendan 17
Ivermectin + Pyrantel As Pamoate Salt 16
Carprofen 13
Hyaluronic Acid 12
Selamectin 10
Ivermectin 8
Oclacitinib 8
Nitenpyram 7
Milbemycin Oxime + Spinosad 7
Imidacloprid + Moxidectin 6
Meloxicam 5
Praziquantel 5
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 4
Levothyroxine Sodium 4
Sarolaner 4
Penicillin G Procaine 3
Pyrantel Pamoate/Praziquantel 3
Trenbolone Acet/Estradiol Impl 3
Ivermectin + Praziquantel 3

Mixed Product Reaction Insights

227 reports name Mixed Product; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 99956.

By species: Unknown (221 reports), Dog (4 reports), Human (1 reports). By breed: Unknown (222), Terrier - Yorkshire (1), Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) (1).

Most co-reported drugs: Afoxolaner (26 reports), Pimobendan (17 reports), Ivermectin + Pyrantel As Pamoate Salt (16 reports), Carprofen (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.