Reaction profile

The FDA adverse-event record for milk fever

17 FDA adverse-event reports reference milk fever (VeDDRA 559). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
47.1%
death-coded share
Cattle
most-affected species
Monensin Sodium
most-associated drug
Verify with FDA CVM →
17
Total Reports
8
Deaths
47.1%
Death Rate

Species Most Affected

Cattle 13
Dog 3
Goat 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 9
Cattle (unknown) 2
Jersey 2
Bulldog 1
Terrier - Yorkshire 1
Great Pyrenees 1
Boer 1

Associated Drugs

Monensin Sodium 12
Pegbovigrastim 3
Calcium 2
Spinosad 1
Vitamins 1
Sodium Chloride 1
Peg-Bfgf-21 1
Moxidectin 1
Maropitant Citrate 1
Rabies Virus, 1
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 1
Canine Influenza Virus H3N8;Canine Influenza Virus H3N2 1
Afoxolaner 1
Ivermectin + Pyrantel As Pamoate Salt 1

Milk fever Reaction Insights

17 reports name Milk fever; 8 recorded a death outcome (47.1% of reported events, not a population-level mortality rate). VeDDRA code: 559.

By species: Cattle (13 reports), Dog (3 reports), Goat (1 reports). By breed: Holstein-Friesian also known as Holstein (9), Cattle (unknown) (2), Jersey (2).

Most co-reported drugs: Monensin Sodium (12 reports), Pegbovigrastim (3 reports), Calcium (2 reports), Spinosad (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.