Reaction profile

The FDA adverse-event record for milk fever

Name: Milk fever - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

17 FDA reports name milk fever, a lower-volume reaction in the CVM extract (VeDDRA 559). Plate stamps and neighbourhood peers follow.

#2247 of 2,481
by report volume (all reactions): 17
reports citing this reaction: 47.1%
death-coded share: Cattle
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Milk fever has 17 reports now versus 17 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Milk fever changes

FDA AER · VeDDRA plate

Code 559 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-MID · BOOK-FULL

VOL-TRACE 17 reports
DEATH-HOT 47.1%
BOTTOM-DECILE #2247/2481
PHOTO-FINISH Anoestrus
SPECIES-CATTLE Cattle · 13
DRUG-LEAD Monensin Sodium · 12
DESK-MID 7 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anoestrus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Milk fever

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Milk fever

Milk fever: high death-coded share in the FDA AER plate

Signature read: 17 reports place Milk fever in the lower third of FDA AER volume (#2247 of 2,481). Report volume is lower-third scale: 17 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 17 reports (47.1% of named reports). Nearest volume peer: Anoestrus (±0 reports). Lead species Cattle (13). Lead co-reported drug Monensin Sodium (12).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 13

Dog 3

Goat 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 9

Cattle (unknown) 2

Jersey 2

Bulldog 1

Terrier - Yorkshire 1

Great Pyrenees 1

Boer 1

Associated Drugs

Monensin Sodium 12

Pegbovigrastim 3

Calcium 2

Spinosad 1

Vitamins 1

Sodium Chloride 1

Peg-Bfgf-21 1

Moxidectin 1

Maropitant Citrate 1

Rabies Virus, 1

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1

Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 1

Canine Influenza Virus H3N8;Canine Influenza Virus H3N2 1

Afoxolaner 1

Ivermectin + Pyrantel As Pamoate Salt 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Milk fever (#2247 of 2,481 by report volume); death-coded 47.1%. PlainBreed reaction plate · report volume stamp 17 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →