Reaction profile

The FDA adverse-event record for mammary gland oedema

114 FDA adverse-event reports reference mammary gland oedema (VeDDRA 528). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1333 of 2,481
by report volume (all reactions)
114
reports citing this reaction
10.5%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Mammary gland oedema has 114 reports now versus 113 in that prior snapshot: 1 more (0.9%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Mammary gland oedema changes

FDA AER · VeDDRA plate

Code 528 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 114 reports
  • DEATH-ELEV 10.5%
  • MID-PACK #1333/2481
  • PHOTO-FINISH Abdominal cramp
  • SPECIES-CATTLE Cattle · 50
  • DRUG-LEAD Sometribove · 12
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal cramp (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Mammary gland oedema

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abdominal cramp · near114Application site oede… · near114Greasy skin · near114Hard stool · near114Mammary gland oedema · this …114Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Mammary gland oedema

What the FDA AER plate says about Mammary gland oedema

Signature read: death-coded share at 10.5% is the most distinctive outcome stamp on Mammary gland oedema. Report volume sits in the middle third of the reaction corpus. 12 of 114 reports were death-coded (10.5% of named reports, not a population mortality rate). Nearest volume peer: Abdominal cramp (±0 reports). Lead species Cattle (50). Lead co-reported drug Sometribove (12).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Sometribove appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 50
Dog 41
Horse 18
Cat 3
Other 1
Goat 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 26
Cattle (unknown) 8
Crossbred Bovine/Cattle 7
Quarter Horse 6
Dog (unknown) 5
Retriever - Labrador 4
Terrier - Yorkshire 4
Jersey 3
Crossbred Canine/dog 3
Horse (unknown) 3

Associated Drugs

Sometribove 12
Cephapirin Benzathine 11
Estradiol 10
Estriol Tablets 10
Altrenogest Oily Solution 10
Monensin Sodium 8
Oclacitinib Maleate 4
Estradiol, Testosterone 3
Cloxacillin Benzathine 3
Carprofen 3
Pergolide Mesylate 3
Cloxacillin Benz Intramam Dc 3
Cephapirin Sodium 2
Milbemycin, Lufenuron 2
Estradiol Benzoate, Progesterone 2
Zeranol Implant 2
Eprinomectin 5 Mg/Ml Pour-On Solution 2
Selamectin 2
Moxidectin 2
Bismuth Subnitr Intramammary 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Mammary gland oedema, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (114 here).

Similar death-coded share

Nearest other reactions by death-coded share (10.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Mammary gland oedema (#1333 of 2,481 by report volume); death-coded 10.5%. PlainBreed reaction plate · death-coded share stamp 10.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →