Reaction profile

The FDA adverse-event record for low liver enzymes

Name: Low liver enzymes - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

17 FDA reports name low liver enzymes, a lower-volume reaction in the CVM extract (VeDDRA 2689). Plate stamps and neighbourhood peers follow.

#2244 of 2,481
by report volume (all reactions): 17
reports citing this reaction: 29.4%
death-coded share: Cat
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Low liver enzymes has 17 reports now versus 17 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Low liver enzymes changes

FDA AER · VeDDRA plate

Code 2689 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 17 reports
DEATH-HOT 29.4%
BOTTOM-DECILE #2244/2481
PHOTO-FINISH Anoestrus
SPECIES-CAT Cat · 8
DRUG-LEAD Trilostane · 6
DESK-WIDE 12 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anoestrus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Low liver enzymes

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Low liver enzymes

Low liver enzymes: high death-coded share in the FDA AER plate

Signature read: 17 reports place Low liver enzymes in the lower third of FDA AER volume (#2244 of 2,481). Report volume is lower-third scale: 17 named reports in the openFDA extract. Death-coded share is upper-third: 5 of 17 reports (29.4% of named reports). Nearest volume peer: Anoestrus (±0 reports). Lead species Cat (8). Lead co-reported drug Trilostane (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 8

Dog 8

Horse 1

Breeds Most Affected

Domestic Shorthair 6

Greyhound - Italian 1

Terrier - Cairn 1

Coonhound - Black and Tan 1

Shepherd Dog - Australian 1

Shepherd Dog - German 1

Terrier - Yorkshire 1

Domestic Mediumhair 1

Retriever - Golden 1

Domestic Longhair 1

Associated Drugs

Trilostane 6

Cyclosporine 3

Maropitant Citrate 3

Feline Calicivirus, Strain F-9, Passage 7, Lot A;Feline Viral Rhinotracheitis, S 2

Robenacoxib Nsaid 2

Oclacitinib Maleate 2

Prednisone 2

Rabies Vaccine 2

Robenacoxib 2

Cefovecin 1

Ampicillin Sodium & Sulbactam Sodium 1

Buprenorphine 1

Ketamine 1

Midazolam Hydrochloride 1

Isoflurane 1

Penicillin 1

Cefazolin 1

Metoclopramide 1

Epinephrine 1

Doxapram Hcl 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Low liver enzymes (#2244 of 2,481 by report volume); death-coded 29.4%. PlainBreed reaction plate · report volume stamp 17 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →