Reaction profile

The FDA adverse-event record for loss of strength

41 FDA reports name loss of strength, a lower-volume reaction in the CVM extract (VeDDRA 1594). Plate stamps and neighbourhood peers follow.

#1839 of 2,481
by report volume (all reactions)
41
reports citing this reaction
22.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Loss of strength has 41 reports now versus 41 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Loss of strength changes

FDA AER · VeDDRA plate

Code 1594 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 41 reports
  • DEATH-HOT 22.0%
  • MID-PACK #1839/2481
  • PHOTO-FINISH Hydrocephalus
  • SPECIES-DOG Dog · 39
  • DRUG-LEAD Bedinvetmab · 15
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hydrocephalus (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Loss of strength

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Hydrocephalus · near41Lack of efficacy (end… · near41Loss of strength · this reac…41Pemphigus · near41Sinusitis · near41Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Loss of strength

What the FDA AER plate says about Loss of strength

Signature read: 41 reports place Loss of strength in the lower third of FDA AER volume (#1839 of 2,481). Report volume is lower-third scale: 41 named reports in the openFDA extract. 9 of 41 reports were death-coded (22.0% of named reports, not a population mortality rate). Nearest volume peer: Hydrocephalus (±0 reports). Lead species Dog (39). Lead co-reported drug Bedinvetmab (15).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 39
Human 1
Cat 1

Breeds Most Affected

Dog (unknown) 4
Crossbred Canine/dog 3
Shepherd Dog - Australian 3
Retriever - Labrador 2
Shepherd Dog - German 2
Terrier - Jack Russell 2
Siberian Husky 2
Terrier (unspecified) 2
Weimaraner 1
Poodle - Miniature 1

Associated Drugs

Bedinvetmab 15
Milbemycin Oxime + Spinosad 11
Carprofen 4
Grapiprant 4
Gabapentin 4
Rabies Vaccine 2
Polysulfated Glycosaminoglycan 2
Afoxolaner 2
Pyrantel Pamoate;Sarolaner 2
Spinosad; Milbemycin Oxime 1
Tacrolimus Ointment 0.03% 1
Distemper Vaccine 1
Bordetella Vaccine 1
Parvo Vaccine 1
Deracoxib 1
Fish Oil Supplements 1
Lufenuron + Milbemycin Oxime 1
Spinosad 1
Fluralaner Chew Tablets 1
Fluralaner 13.64% 12-Week Chew 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Loss of strength (#1839 of 2,481 by report volume); death-coded 22.0%. PlainBreed reaction plate · report volume stamp 41 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →