Reaction profile

The FDA adverse-event record for loss of strength

38 FDA adverse-event reports reference loss of strength (VeDDRA 1594). See the species, breeds, and drugs most associated with it below.

38
reports citing this reaction
21.1%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
38
Total Reports
8
Deaths
21.1%
Death Rate

Species Most Affected

Dog 36
Human 1
Cat 1

Breeds Most Affected

Dog (unknown) 4
Shepherd Dog - Australian 3
Retriever - Labrador 2
Shepherd Dog - German 2
Siberian Husky 2
Terrier (unspecified) 2
Weimaraner 1
Poodle - Miniature 1
Spaniel - Cocker American 1
Pit Bull 1

Associated Drugs

Bedinvetmab 13
Milbemycin Oxime + Spinosad 11
Carprofen 4
Grapiprant 4
Gabapentin 4
Rabies Vaccine 2
Pyrantel Pamoate;Sarolaner 2
Spinosad; Milbemycin Oxime 1
Tacrolimus Ointment 0.03% 1
Distemper Vaccine 1
Bordetella Vaccine 1
Parvo Vaccine 1
Deracoxib 1
Fish Oil Supplements 1
Lufenuron + Milbemycin Oxime 1
Polysulfated Glycosaminoglycan 1
Spinosad 1
Fluralaner Chew Tablets 1
Afoxolaner 1
Fluralaner 13.64% 12-Week Chew 1

Loss of strength Reaction Insights

38 reports name Loss of strength; 8 recorded a death outcome (21.1% of reported events, not a population-level mortality rate). VeDDRA code: 1594.

By species: Dog (36 reports), Human (1 reports), Cat (1 reports). By breed: Dog (unknown) (4), Shepherd Dog - Australian (3), Retriever - Labrador (2).

Most co-reported drugs: Bedinvetmab (13 reports), Milbemycin Oxime + Spinosad (11 reports), Carprofen (4 reports), Grapiprant (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.