Reaction profile

The FDA adverse-event record for loss of concentration

11 FDA adverse-event reports reference loss of concentration (VeDDRA 1589). See the species, breeds, and drugs most associated with it below.

11
reports citing this reaction
9.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
11
Total Reports
1
Deaths
9.1%
Death Rate

Species Most Affected

Dog 8
Cat 2
Human 1

Breeds Most Affected

Domestic Shorthair 2
Unknown 1
Pointing Dog - German Short-haired 1
Terrier - Bull 1
Shih Tzu 1
Dog (unknown) 1
Crossbred Canine/dog 1
Poodle (unspecified) 1
Terrier (unspecified) 1
Coton de Tuléar 1

Associated Drugs

Milbemycin Oxime + Spinosad 4
Buprenorphine 3
Maropitant Citrate 2
Spinosad 1
Phenytoin Sodium 1
Afoxolaner 1
Fluoxetine 1
Milk Thistle 1
Rabies Vaccine 1
Distemper Vaccine 1
Zonisamide 1
Fluralaner Chew Tablets 1
Pyrantel Pamoate;Sarolaner 1
Meloxicam 1
Amoxicillin + Clavulanic Acid 1
Gabapentin 1
Dexmedetomidine 1
Propofol 1
Anesthesia (Gas) 1
Naloxone 1

Loss of concentration Reaction Insights

11 reports name Loss of concentration; 1 recorded a death outcome (9.1% of reported events, not a population-level mortality rate). VeDDRA code: 1589.

By species: Dog (8 reports), Cat (2 reports), Human (1 reports). By breed: Domestic Shorthair (2), Unknown (1), Pointing Dog - German Short-haired (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (4 reports), Buprenorphine (3 reports), Maropitant Citrate (2 reports), Spinosad (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.