Reaction profile

The FDA adverse-event record for liver fibrosis

Name: Liver fibrosis - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

38 FDA reports name liver fibrosis, a lower-volume reaction in the CVM extract (VeDDRA 490). Plate stamps and neighbourhood peers follow.

#1879 of 2,481
by report volume (all reactions): 38
reports citing this reaction: 71.1%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver fibrosis has 38 reports now versus 37 in that prior snapshot: 1 more (2.7%).

Report change: +1
Death-coded reports: +1
Death-coded share: +0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Liver fibrosis changes

FDA AER · VeDDRA plate

Code 490 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 38 reports
DEATH-HOT 71.1%
LOWER-Q #1879/2481
PHOTO-FINISH Clenched jaw
SPECIES-DOG Dog · 34
DRUG-LEAD Spinosad · 6
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Clenched jaw (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Liver fibrosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Liver fibrosis

Liver fibrosis: high death-coded share in the FDA AER plate

Signature read: Liver fibrosis's 71.1% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 38 named reports in the openFDA extract. Death-coded share is upper-third: 27 of 38 reports (71.1% of named reports). Nearest volume peer: Clenched jaw (±0 reports). Lead species Dog (34). Lead co-reported drug Spinosad (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 34

Cat 2

Cattle 1

Horse 1

Breeds Most Affected

Shepherd Dog - German 3

Schnauzer - Miniature 2

Beagle 2

Crossbred Canine/dog 2

Terrier - Bull - American Pit 1

Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1

Spaniel - Springer (unspecified) 1

Pinscher - Miniature 1

Poodle - Standard 1

Cattle (unknown) 1

Associated Drugs

Spinosad 6

Milbemycin Oxime + Spinosad 5

Carprofen 4

Fluralaner 13.64% 12-Week Chew 3

Moxidectin 2

Firocoxib 2

Gabapentin 2

Afoxolaner 2

Doxycycline 2

Fluralaner Chew Tablets 2

Milbemycin Oxime + Praziquantel 2

Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1

Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 1

Dinotefuran, Pyriproxyfen 1

Pyrantel Pamoate 1

Bordetella Bronchiseptica, Strain 78-9159, Kb 1

Firocoxib 57 Mg Chewable 1

Monensin Sodium 1

Firocoxib 227 Mg Chewable 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Liver fibrosis (#1879 of 2,481 by report volume); death-coded 71.1%. PlainBreed reaction plate · death-coded share stamp 71.1% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →