Reaction profile

The FDA adverse-event record for liver degeneration

29 FDA reports name liver degeneration, a lower-volume reaction in the CVM extract (VeDDRA 2120). Plate stamps and neighbourhood peers follow.

#2016 of 2,481
by report volume (all reactions)
29
reports citing this reaction
69.0%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver degeneration has 29 reports now versus 29 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Liver degeneration changes

FDA AER · VeDDRA plate

Code 2120 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 29 reports
  • DEATH-HOT 69.0%
  • LOWER-Q #2016/2481
  • PHOTO-FINISH Application site mois…
  • SPECIES-DOG Dog · 20
  • DRUG-LEAD Fluralaner Chew T… · 4
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site moist eczema (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Liver degeneration

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site mois… · near29Blue eye · near29Enteric pathogen NOS · near29Generalised skin slou… · near29Liver degeneration · this re…29Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Liver degeneration

Liver degeneration: high death-coded share in the FDA AER plate

Signature read: Liver degeneration's 69.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 29 named reports in the openFDA extract. Death-coded share is upper-third: 20 of 29 reports (69.0% of named reports). Nearest volume peer: Application site moist eczema (±0 reports). Lead species Dog (20). Lead co-reported drug Fluralaner Chew Tablets (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 20
Cat 5
Cattle 3
Chicken 1

Breeds Most Affected

Crossbred Canine/dog 3
Domestic Shorthair 3
Pinscher - Miniature 2
Shepherd Dog - Australian 2
Retriever - Labrador 2
Dachshund (unspecified) 2
Holstein-Friesian also known as Holstein 2
Chicken (unknown) 1
Dog (unknown) 1
Shih Tzu 1

Associated Drugs

Fluralaner Chew Tablets 4
Monensin Sodium 3
Maropitant Citrate 3
Buprenorphine 3
Milbemycin Oxime + Spinosad 2
Carprofen 2
Imidacloprid + Moxidectin 2
Milbemycin/Lufenuron Tablets 2
Verdinexor 2
Spinosad 1
Insulin 1
Insulin Injectable Vial 1
Vitamin B 1
Amlodipine 1
Laxatone 1
Fortiflora 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Metronidazole 1
Sam-E, Silybin, Vitamin E, Zinc 1
Ursodiol 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Liver degeneration (#2016 of 2,481 by report volume); death-coded 69.0%. PlainBreed reaction plate · death-coded share stamp 69.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →