Reaction profile

The FDA adverse-event record for liver damage aggravated

11 FDA reports name liver damage aggravated, a lower-volume reaction in the CVM extract (VeDDRA 1579). Plate stamps and neighbourhood peers follow.

#2430 of 2,481
by report volume (all reactions)
11
reports citing this reaction
72.7%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver damage aggravated has 11 reports now versus 11 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Liver damage aggravated changes

FDA AER · VeDDRA plate

Code 1579 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 11 reports
  • DEATH-HOT 72.7%
  • BOTTOM-DECILE #2430/2481
  • PHOTO-FINISH ABNORMAL PANCREATIC S…
  • SPECIES-DOG Dog · 9
  • DRUG-LEAD Oclacitinib Malea… · 4
  • DESK-WIDE 11 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Liver damage aggravated

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ABNORMAL PANCREATIC S… · near11Aortic stenosis · near11Aqueous flare · near11Bile duct inflammation · near11Liver damage aggravat… · thi…11Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Liver damage aggravated

Liver damage aggravated: high death-coded share in the FDA AER plate

Signature read: 11 reports place Liver damage aggravated in the lower third of FDA AER volume (#2430 of 2,481). Report volume is lower-third scale: 11 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 11 reports (72.7% of named reports). Nearest volume peer: ABNORMAL PANCREATIC SPECIFIC LIPASE (PLI) (±0 reports). Lead species Dog (9). Lead co-reported drug Oclacitinib Maleate (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 9
Rabbit 1
Cat 1

Breeds Most Affected

Terrier - Scottish 1
Terrier - Cairn 1
Dachshund - Miniature 1
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) 1
Crossbred Canine/dog 1
Bulldog - American 1
Retriever - Golden 1
Californian 1
Schnauzer - Miniature 1
Dog (unknown) 1

Associated Drugs

Oclacitinib Maleate 4
Milbemycin Oxime + Spinosad 2
Spinosad 2
Afoxolaner 1
Penicillin G Procaine 1
Prednisone 1
Diazepam 1
Fluralaner Chew Tablets 1
Rabies In Hhh Adj Pfizer Kv 1
Da2Ppv+L*4 (Orig S-P Us) Lv+Kb 1
Canine Bb/Pi3/Adeno 2 Lv/Lb 1
Carprofen 1
Fluralaner Spot-On Solution 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Liver damage aggravated (#2430 of 2,481 by report volume); death-coded 72.7%. PlainBreed reaction plate · report volume stamp 11 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →