Reaction profile

The FDA adverse-event record for lip paralysis

28 FDA adverse-event reports reference lip paralysis (VeDDRA 1151). See the species, breeds, and drugs most associated with it below.

28
reports citing this reaction
7.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
28
Total Reports
2
Deaths
7.1%
Death Rate

Species Most Affected

Dog 20
Horse 7
Mule 1

Breeds Most Affected

Boxer (German Boxer) 3
Pit Bull 3
Quarter Horse 2
Bulldog - French 2
Rottweiler 1
Shiba Inu 1
Retriever - Labrador 1
Retriever - Golden 1
Shepherd Dog - German 1
Warmblood (unspecified) 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 4
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 4
Oclacitinib Maleate 2
Prednisone 2
Enrofloxacin 2
Maropitant Citrate 2
Diphenhydramine 2
Florfenicol + Mometasone Furoate + Terbinafine 2
Insulin (Unknown) 1
Melarsomine Dihydrochloride Injection 1
Firocoxib 227 Mg Chewable 1
Trilostane 1
Compounded Trilostane 1
Pimobendan 1
Meclizine 1
Ivermectin 1.87% Paste 1
Afoxolaner 1
Ivermectin + Pyrantel As Pamoate Salt 1
Levothyroxine Sodium 1

Lip paralysis Reaction Insights

28 reports name Lip paralysis; 2 recorded a death outcome (7.1% of reported events, not a population-level mortality rate). VeDDRA code: 1151.

By species: Dog (20 reports), Horse (7 reports), Mule (1 reports). By breed: Boxer (German Boxer) (3), Pit Bull (3), Quarter Horse (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Ivermectin(1.55%)/Praziquantel(7.75%) Paste (4 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (4 reports), Oclacitinib Maleate (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.