Reaction profile

The FDA adverse-event record for absence seizure

28 FDA adverse-event reports reference absence seizure (VeDDRA 1295). See the species, breeds, and drugs most associated with it below.

28
reports citing this reaction
10.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
28
Total Reports
3
Deaths
10.7%
Death Rate

Species Most Affected

Dog 26
Horse 1
Cat 1

Breeds Most Affected

Retriever - Labrador 5
Crossbred Canine/dog 4
Chihuahua 2
Terrier - Yorkshire 1
Schnauzer (unspecified) 1
Maltese 1
Schnauzer - Miniature 1
Spaniel - Cocker American 1
Boxer (German Boxer) 1
Shepherd Dog - German 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Sarolaner 3
Pyrantel Pamoate;Sarolaner 3
Spinosad 2
Oclacitinib Maleate 2
Fluralaner Chew Tablets 2
Lotilaner 2
Bedinvetmab 2
Lufenuron + Milbemycin Oxime 1
Phenobarbital 1
Ivermectin + Pyrantel Pamoate 1
Firocoxib 57 Mg Chewable 1
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 1
Firocoxib 227 Mg Chewable 1
Carprofen 1
Vaccines (Unknown) 1
Afoxolaner 136 Mg Chewable Tablets 1
Imidacloprid/Moxidectin 1
Milbemycin Oxime/Praziquantel 1
Milbemycin Oxime 1

Absence seizure Reaction Insights

28 reports name Absence seizure; 3 recorded a death outcome (10.7% of reported events, not a population-level mortality rate). VeDDRA code: 1295.

By species: Dog (26 reports), Horse (1 reports), Cat (1 reports). By breed: Retriever - Labrador (5), Crossbred Canine/dog (4), Chihuahua (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Sarolaner (3 reports), Pyrantel Pamoate;Sarolaner (3 reports), Spinosad (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.