Reaction profile

The FDA adverse-event record for leucopenia

18 FDA reports name leucopenia, a lower-volume reaction in the CVM extract (VeDDRA 164). Plate stamps and neighbourhood peers follow.

#2217 of 2,481
by report volume (all reactions)
18
reports citing this reaction
44.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Leucopenia has 18 reports now versus 18 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Leucopenia changes

FDA AER · VeDDRA plate

Code 164 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 18 reports
  • DEATH-HOT 44.4%
  • LOWER-Q #2217/2481
  • PHOTO-FINISH ALBUMIN/GLOBULIN RATI…
  • SPECIES-DOG Dog · 15
  • DRUG-LEAD Milbemycin Oxime… · 3
  • DESK-WIDE 14 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Leucopenia

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ALBUMIN/GLOBULIN RATI… · near18Application site skin… · near18Bone marrow hypoplasia · near18Cognitive disturbance · near18Leucopenia · this reaction18Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Leucopenia

Leucopenia: high death-coded share in the FDA AER plate

Signature read: 18 reports place Leucopenia in the lower third of FDA AER volume (#2217 of 2,481). Report volume is lower-third scale: 18 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 18 reports (44.4% of named reports). Nearest volume peer: ALBUMIN/GLOBULIN RATIO HI, BLD (±0 reports). Lead species Dog (15). Lead co-reported drug Milbemycin Oxime + Spinosad (3).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 15
Cat 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 2
Greyhound 2
Retriever - Labrador 2
Shih Tzu 2
Lhasa Apso 1
Cattle (other) 1
Poodle (unspecified) 1
Coton de Tuléar 1
Mixed (Dog) 1
Crossbred Canine/dog 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Maropitant Citrate 3
Cefovecin 2
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 2
Oclacitinib 2
Ursodiol 1
Amoxicillin As Trihydrate 1
Ampicillin Sodium & Sulbactam Sodium 1
Enrofloxacin 1
Doxycycline 1
Plasma 1
Buprenorphine 1
Tulathromycin 1
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 1
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 1
Bovine Parainfluenza Virus 3, Reisinger(Nl-Bk-6), Mlv; Bovine Respiratory Syncyt 1
Albendazole 1
Multi-Vitamin 1
Tobramycin And Dexamethasone Ophthalmic 1
Demecarium Bromide 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Leucopenia (#2217 of 2,481 by report volume); death-coded 44.4%. PlainBreed reaction plate · report volume stamp 18 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →