Reaction profile

The FDA adverse-event record for leucopenia

18 FDA adverse-event reports reference leucopenia (VeDDRA 164). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
44.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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18
Total Reports
8
Deaths
44.4%
Death Rate

Species Most Affected

Dog 15
Cat 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 2
Greyhound 2
Retriever - Labrador 2
Shih Tzu 2
Lhasa Apso 1
Cattle (other) 1
Poodle (unspecified) 1
Coton de Tuléar 1
Mixed (Dog) 1
Crossbred Canine/dog 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Maropitant Citrate 3
Cefovecin 2
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 2
Oclacitinib 2
Ursodiol 1
Amoxicillin As Trihydrate 1
Ampicillin Sodium & Sulbactam Sodium 1
Enrofloxacin 1
Doxycycline 1
Plasma 1
Buprenorphine 1
Tulathromycin 1
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 1
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 1
Bovine Parainfluenza Virus 3, Reisinger(Nl-Bk-6), Mlv; Bovine Respiratory Syncyt 1
Albendazole 1
Multi-Vitamin 1
Tobramycin And Dexamethasone Ophthalmic 1
Demecarium Bromide 1

Leucopenia Reaction Insights

18 reports name Leucopenia; 8 recorded a death outcome (44.4% of reported events, not a population-level mortality rate). VeDDRA code: 164.

By species: Dog (15 reports), Cat (2 reports), Cattle (1 reports). By breed: Domestic Shorthair (2), Greyhound (2), Retriever - Labrador (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Maropitant Citrate (3 reports), Cefovecin (2 reports), Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.