Reaction profile

The FDA adverse-event record for lacrimation increased

42 FDA adverse-event reports reference lacrimation increased (VeDDRA 1572). See the species, breeds, and drugs most associated with it below.

42
reports citing this reaction
2.4%
death-coded share
Dog
most-affected species
Emodepside + Praziquantel
most-associated drug
Verify with FDA CVM →
42
Total Reports
1
Deaths
2.4%
Death Rate

Species Most Affected

Dog 22
Cat 11
Human 5
Cattle 3
Goat 1

Breeds Most Affected

Domestic Shorthair 9
Unknown 5
Maltese 4
Chihuahua 3
Retriever - Labrador 2
Shih Tzu 1
Beagle 1
Shepherd Dog - German 1
Weimaraner 1
Cattle (other) 1

Associated Drugs

Emodepside + Praziquantel 4
Milbemycin Oxime + Spinosad 4
Imidacloprid + Moxidectin 3
Afoxolaner 3
Selamectin 3
Afoxolaner 11.3 Mg Chewable Tablets 3
Spinosad 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Nitenpyram 2
Milbemycin Oxime + Praziquantel 2
Praziquantel 2
Oxytetracycline Hcl; Polymyxin B Sulfate 1
Contact Lens 1
Ceftiofur Crystalline Free Acid 1
Flunixin + Oxytetracycline 1
Monensin Sodium 1
Moraxella Bovis Bacterin 1
Trace Mineral Supplement (Unknown) 1
Unspecifed Insulin 1
Genta/Momet/Clotrim Ear Oint 1

Lacrimation increased Reaction Insights

42 reports name Lacrimation increased; 1 recorded a death outcome (2.4% of reported events, not a population-level mortality rate). VeDDRA code: 1572.

By species: Dog (22 reports), Cat (11 reports), Human (5 reports). By breed: Domestic Shorthair (9), Unknown (5), Maltese (4).

Most co-reported drugs: Emodepside + Praziquantel (4 reports), Milbemycin Oxime + Spinosad (4 reports), Imidacloprid + Moxidectin (3 reports), Afoxolaner (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.