Reaction profile

The FDA adverse-event record for lacrimation increased

45 FDA reports name lacrimation increased, a lower-volume reaction in the CVM extract (VeDDRA 1572). Plate stamps and neighbourhood peers follow.

#1795 of 2,481
by report volume (all reactions)
45
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lacrimation increased has 45 reports now versus 44 in that prior snapshot: 1 more (2.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lacrimation increased changes

FDA AER · VeDDRA plate

Code 1572 VOL-TRACE

VOL-TRACE · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 45 reports
  • DEATH-LOW 2.2%
  • MID-PACK #1795/2481
  • PHOTO-FINISH Application site disc…
  • SPECIES-DOG Dog · 23
  • DRUG-LEAD Emodepside + Praz… · 5
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site discharge NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Lacrimation increased

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Application site disc… · near45Buccal irritation · near45Chest tightness · near45Flaccid paralysis · near45Lacrimation increased · this…45Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lacrimation increased

Lacrimation increased: low death-coded share in the FDA AER plate

Signature read: 1 death-coded reports is a thin tail count for Lacrimation increased in the CVM extract. Report volume is lower-third scale: 45 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 45 reports (2.2% of named reports). Nearest volume peer: Application site discharge NOS (±0 reports). Lead species Dog (23). Lead co-reported drug Emodepside + Praziquantel (5).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Emodepside + Praziquantel appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 23
Cat 13
Human 5
Cattle 3
Goat 1

Breeds Most Affected

Domestic Shorthair 9
Unknown 5
Maltese 4
Retriever - Labrador 3
Chihuahua 3
Domestic Longhair 2
Shih Tzu 1
Beagle 1
Shepherd Dog - German 1
Weimaraner 1

Associated Drugs

Emodepside + Praziquantel 5
Milbemycin Oxime + Spinosad 4
Imidacloprid + Moxidectin 3
Afoxolaner 3
Selamectin 3
Afoxolaner 11.3 Mg Chewable Tablets 3
Spinosad 2
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Nitenpyram 2
Praziquantel 2
Milbemycin Oxime + Praziquantel 2
Lotilaner 2
Oxytetracycline Hcl; Polymyxin B Sulfate 1
Contact Lens 1
Ceftiofur Crystalline Free Acid 1
Flunixin + Oxytetracycline 1
Monensin Sodium 1
Moraxella Bovis Bacterin 1
Trace Mineral Supplement (Unknown) 1
Unspecifed Insulin 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lacrimation increased (#1795 of 2,481 by report volume); death-coded 2.2%. PlainBreed reaction plate · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →