Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - trematode

42 FDA adverse-event reports reference lack of efficacy (endoparasite) - trematode (VeDDRA 2659). See the species, breeds, and drugs most associated with it below.

42
reports citing this reaction
33.3%
death-coded share
Cattle
most-affected species
Albendazole
most-associated drug
Verify with FDA CVM →
42
Total Reports
14
Deaths
33.3%
Death Rate

Species Most Affected

Cattle 23
Dog 14
Sheep 2
Cat 2
Unknown 1

Breeds Most Affected

Mixed (Cattle) 7
Cattle (unknown) 6
Cattle (other) 3
Retriever - Labrador 3
Aberdeen Angus 3
Crossbred Bovine/Cattle 2
Sheep (unknown) 2
Terrier - Boston 2
Pug 1
Murray Gray 1

Associated Drugs

Albendazole 14
Ivermectin(1%)/Clorsulon(10%) Injection 7
Ivermectin + Pyrantel As Pamoate Salt 4
Pyrantel Pamoate;Sarolaner 3
Clorsulon, Ivermectin 2
Milbemycin Oxime + Spinosad 2
Eprinomectin 5 Mg/Ml Pour-On Solution 2
Clostridium Chauvoei, Strain F, Lot No. 2-84;Clostridium Haemolyticum, Strain Ir 2
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1
Lufenuron + Milbemycin Oxime 1
Clostridium Chauvoei, Strain F, Lot No. 2-84; Clostridium Haemolyticum, Strain I 1
Insulin (Unknown) 1
Fipronil 1
Milbemycin Oxime 1
Eprinomectin 1
Doramectin; Phenol 1
Portech App Gun 65 Ml Ivomec/Eprinex 1
Milbemycin Oxime, Lufenuron 1
Fenbendazol Suspension 1
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot 062901D;Bovine Viral Diar 1

Lack of efficacy (endoparasite) - trematode Reaction Insights

42 reports name Lack of efficacy (endoparasite) - trematode; 14 recorded a death outcome (33.3% of reported events, not a population-level mortality rate). VeDDRA code: 2659.

By species: Cattle (23 reports), Dog (14 reports), Sheep (2 reports). By breed: Mixed (Cattle) (7), Cattle (unknown) (6), Cattle (other) (3).

Most co-reported drugs: Albendazole (14 reports), Ivermectin(1%)/Clorsulon(10%) Injection (7 reports), Ivermectin + Pyrantel As Pamoate Salt (4 reports), Pyrantel Pamoate;Sarolaner (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.