Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - trematode

Name: Lack of efficacy (endoparasite) - trematode - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

43 FDA reports name lack of efficacy (endoparasite) - trematode, a lower-volume reaction in the CVM extract (VeDDRA 2659). Plate stamps and neighbourhood peers follow.

#1815 of 2,481
by report volume (all reactions): 43
reports citing this reaction: 32.6%
death-coded share: Cattle
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (endoparasite) - trematode has 43 reports now versus 42 in that prior snapshot: 1 more (2.4%).

Report change: +1
Death-coded reports: +0
Death-coded share: −0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (endoparasite) - trematode changes

FDA AER · VeDDRA plate

Code 2659 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 43 reports
DEATH-HOT 32.6%
MID-PACK #1815/2481
PHOTO-FINISH Application site numb…
SPECIES-CATTLE Cattle · 24
DRUG-LEAD Albendazole · 14
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Application site numbness (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Lack of efficacy - trematode

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Lack of efficacy (endoparasite) - trematode

Lack of efficacy (endoparasite) - trematode: high death-coded share in the FDA AER plate

Signature read: Lack of efficacy (endoparasite) - trematode's 32.6% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 43 named reports in the openFDA extract. Death-coded share is upper-third: 14 of 43 reports (32.6% of named reports). Nearest volume peer: Application site numbness (±0 reports). Lead species Cattle (24). Lead co-reported drug Albendazole (14).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 24

Dog 14

Sheep 2

Cat 2

Unknown 1

Breeds Most Affected

Mixed (Cattle) 7

Cattle (unknown) 6

Cattle (other) 4

Retriever - Labrador 3

Aberdeen Angus 3

Crossbred Bovine/Cattle 2

Sheep (unknown) 2

Terrier - Boston 2

Pug 1

Murray Gray 1

Associated Drugs

Albendazole 14

Ivermectin(1%)/Clorsulon(10%) Injection 7

Ivermectin + Pyrantel As Pamoate Salt 4

Pyrantel Pamoate;Sarolaner 3

Clorsulon, Ivermectin 2

Milbemycin Oxime + Spinosad 2

Eprinomectin 5 Mg/Ml Pour-On Solution 2

Clostridium Chauvoei, Strain F, Lot No. 2-84;Clostridium Haemolyticum, Strain Ir 2

Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1

Lufenuron + Milbemycin Oxime 1

Clostridium Chauvoei, Strain F, Lot No. 2-84; Clostridium Haemolyticum, Strain I 1

Insulin (Unknown) 1

Fipronil 1

Milbemycin Oxime 1

Eprinomectin 1

Doramectin; Phenol 1

Portech App Gun 65 Ml Ivomec/Eprinex 1

Milbemycin Oxime, Lufenuron 1

Fenbendazol Suspension 1

Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot 062901D;Bovine Viral Diar 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (endoparasite) - trematode (#1815 of 2,481 by report volume); death-coded 32.6%. PlainBreed reaction plate · death-coded share stamp 32.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →