Lack of efficacy (endoparasite) - strongylids

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VeDDRA Code: 2825

38 adverse event reports referencing this reaction

38
Total Reports
3
Deaths
790.0%
Death Rate

Species Most Affected

Dog 17
Horse 12
Cattle 5
Frog 1
Other 1
Goat 1
Sheep 1

Breeds Most Affected

Thoroughbred 3
Retriever - Golden 3
Catahoula Leopard Dog 3
Unknown 2
Crossbred Canine/dog 2
Crossbred Equine/horse 2
Horse (unknown) 2
Cattle (other) 2
Mustang 2
Paint 2

Associated Drugs

Praziquantel;Moxidectin 8
Moxidectin 6
Pyrantel Pamoate;Sarolaner 5
Fenbendazol Suspension 4
Milbemycin Oxime + Praziquantel 4
Panacur 4
Oxybendazole 4
Ivermectin Paste 1.87% 4
Ivermectin 3
Eprinomectin 3
Ivermectin + Pyrantel As Pamoate Salt 3
Ivermectin/Praziquantel 1
Milbemycin Oxime 1
Fenbendazol Oral Paste 1
Imidacloprid + Moxidectin 1
Febantel + Praziquantel + Pyrantel Pamoate 1
Fenbendazole 1
Doramectin 1
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 1
Milbemycin/Lufenuron/Pzq Chew 1

Data Summary

Metric Value
Total reports referencing reaction 38
Reports with fatal outcome 3
Case-fatality rate (reported events) 790.0%
Species observed 7
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2825.

Lack of efficacy (endoparasite) - strongylids Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 38 adverse event reports that reference Lack of efficacy (endoparasite) - strongylids as a reaction term, including 3 reports with a death outcome — a 790.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2825, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Lack of efficacy (endoparasite) - strongylids appears most frequently in reports for Dog (17 reports), Horse (12 reports), Cattle (5 reports) — with Dog dominating at 17 entries. Within those species, the breeds most often named alongside this reaction are Thoroughbred (3), Retriever - Golden (3), Catahoula Leopard Dog (3). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Lack of efficacy (endoparasite) - strongylids are Praziquantel;Moxidectin (8 reports), Moxidectin (6 reports), Pyrantel Pamoate;Sarolaner (5 reports), Fenbendazol Suspension (4 reports), with Praziquantel;Moxidectin appearing alongside this reaction in 8 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial