Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - strongylids

38 FDA adverse-event reports reference lack of efficacy (endoparasite) - strongylids (VeDDRA 2825). See the species, breeds, and drugs most associated with it below.

38
reports citing this reaction
7.9%
death-coded share
Dog
most-affected species
Praziquantel;Moxidectin
most-associated drug
Verify with FDA CVM →
38
Total Reports
3
Deaths
7.9%
Death Rate

Species Most Affected

Dog 17
Horse 12
Cattle 5
Frog 1
Other 1
Goat 1
Sheep 1

Breeds Most Affected

Thoroughbred 3
Retriever - Golden 3
Catahoula Leopard Dog 3
Unknown 2
Crossbred Canine/dog 2
Crossbred Equine/horse 2
Horse (unknown) 2
Cattle (other) 2
Mustang 2
Paint 2

Associated Drugs

Praziquantel;Moxidectin 8
Moxidectin 6
Pyrantel Pamoate;Sarolaner 5
Fenbendazol Suspension 4
Milbemycin Oxime + Praziquantel 4
Panacur 4
Oxybendazole 4
Ivermectin Paste 1.87% 4
Ivermectin 3
Eprinomectin 3
Ivermectin + Pyrantel As Pamoate Salt 3
Ivermectin/Praziquantel 1
Milbemycin Oxime 1
Fenbendazol Oral Paste 1
Imidacloprid + Moxidectin 1
Febantel + Praziquantel + Pyrantel Pamoate 1
Fenbendazole 1
Doramectin 1
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 1
Milbemycin/Lufenuron/Pzq Chew 1

Lack of efficacy (endoparasite) - strongylids Reaction Insights

38 reports name Lack of efficacy (endoparasite) - strongylids; 3 recorded a death outcome (7.9% of reported events, not a population-level mortality rate). VeDDRA code: 2825.

By species: Dog (17 reports), Horse (12 reports), Cattle (5 reports). By breed: Thoroughbred (3), Retriever - Golden (3), Catahoula Leopard Dog (3).

Most co-reported drugs: Praziquantel;Moxidectin (8 reports), Moxidectin (6 reports), Pyrantel Pamoate;Sarolaner (5 reports), Fenbendazol Suspension (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.