Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - rickettsia

Name: Lack of efficacy (bacteria) - Rickettsia - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

43 FDA reports name lack of efficacy (bacteria) - rickettsia, a lower-volume reaction in the CVM extract (VeDDRA 3133). Plate stamps and neighbourhood peers follow.

#1814 of 2,481
by report volume (all reactions): 43
reports citing this reaction: 2.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

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Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (bacteria) - Rickettsia has 43 reports now versus 39 in that prior snapshot: 4 more (10.3%).

Report change: +4
Death-coded reports: +0
Death-coded share: −0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (bacteria) - Rickettsia changes

FDA AER · VeDDRA plate

Code 3133 VOL-TRACE

VOL-TRACE · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 43 reports
DEATH-LOW 2.3%
MID-PACK #1814/2481
PHOTO-FINISH Application site numb…
SPECIES-DOG Dog · 43
DRUG-LEAD Pyrantel Pamoate;… · 15
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Application site numbness (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Lack of efficacy - Rickettsia

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Lack of efficacy (bacteria) - Rickettsia

Lack of efficacy (bacteria) - Rickettsia: low death-coded share in the FDA AER plate

Signature read: 1 death-coded reports is a thin tail count for Lack of efficacy (bacteria) - Rickettsia in the CVM extract. Report volume is lower-third scale: 43 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 43 reports (2.3% of named reports). Nearest volume peer: Application site numbness (±0 reports). Lead species Dog (43). Lead co-reported drug Pyrantel Pamoate;Sarolaner (15).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pyrantel Pamoate;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 43

Breeds Most Affected

Crossbred Canine/dog 8

Dog (unknown) 6

Retriever - Labrador 5

Retriever - Golden 4

Shepherd Dog - German 4

Siberian Husky 2

Spaniel - King Charles Cavalier 1

Portuguese Water Dog 1

Schnauzer - Miniature 1

Dog (other) 1

Associated Drugs

Pyrantel Pamoate;Sarolaner 15

Afoxolaner 15

Fluralaner 13.64% 12-Week Chew 5

Sarolaner 3

Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 3

Ivermectin + Pyrantel As Pamoate Salt 2

Selamectin 1

Capromorelin 1

Leptospira Canicola, Hond Urecht Strain,Leptospira Grippotyphosa, F4397 Strain,Leptospira Icterohaemorrhagiae, Copenhageni Strain,Leptospira Pomona, Kennewicki Strain 1

Gabapentin 1

Doxycycline 1

Enrofloxacin 1

S-Adenosylmethionine + Silybin 1

Sarolaner,Moxidectin,Pyrantel 1

Amoxicillin + Clavulanic Acid 1

Fluralaner 5.46% 1-Month Chew 1

Carprofen 1

Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 1

Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 1

Moxidectin 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (bacteria) - Rickettsia (#1814 of 2,481 by report volume); death-coded 2.3%. PlainBreed reaction plate · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →