Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - e.coli

25 FDA adverse-event reports reference lack of efficacy (bacteria) - e.coli (VeDDRA 2786). See the species, breeds, and drugs most associated with it below.

25
reports citing this reaction
52.0%
death-coded share
Cattle
most-affected species
Ceftiofur
most-associated drug
Verify with FDA CVM →
25
Total Reports
13
Deaths
52.0%
Death Rate

Species Most Affected

Cattle 16
Pig 5
Dog 3
Cat 1

Breeds Most Affected

Cattle (other) 8
Holstein-Friesian also known as Holstein 6
Crossbred Porcine/Pig 2
Crossbred Bovine/Cattle 1
Mixed (Cattle) 1
Retriever - Labrador 1
Pig (unknown) 1
Cat (other) 1
Mixed (Pig) 1
Beagle 1

Associated Drugs

Ceftiofur 6
Tulathromycin 6
Enrofloxacin 5
Cloxacillin Benz Intramam Dc 4
Florfenicol 4
Bovine Rhinotracheitis + Virus Diarrhea + Parainfluenza 3 + Respiratory Syncytial Virus Vaccine 4
Cloxacillin Benzathine 3
Bismuth Subnitrate 60% Intramammary 3
Sodium Chloride 3
Dewormer (Unknown) 3
Tildipirosin 3
Dexamethasone 3
E. Coli Strain J-5 Kb 2
Ampicillin Trihydrate 2
Monensin Sodium 2
Danofloxacin 2
Avilamycin 2
Tylosin 2
Porcine Reproductive And Respiratory Syndrome Virus, Sd11-21 Strain 2
Bordetella Bronchiseptica, Field Strain,Erysipelothrix Rhusiopathiae, Se-9 Strain,Pasteurella Multocida, 169 Strain,Pasteurella Multocida, Type D, Atcc 12948 Strain 2

Lack of efficacy (bacteria) - E.coli Reaction Insights

25 reports name Lack of efficacy (bacteria) - E.coli; 13 recorded a death outcome (52.0% of reported events, not a population-level mortality rate). VeDDRA code: 2786.

By species: Cattle (16 reports), Pig (5 reports), Dog (3 reports). By breed: Cattle (other) (8), Holstein-Friesian also known as Holstein (6), Crossbred Porcine/Pig (2).

Most co-reported drugs: Ceftiofur (6 reports), Tulathromycin (6 reports), Enrofloxacin (5 reports), Cloxacillin Benz Intramam Dc (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.