Reaction profile

The FDA adverse-event record for joint cartilage disorder nos

35 FDA adverse-event reports reference joint cartilage disorder nos (VeDDRA 2243). See the species, breeds, and drugs most associated with it below.

35
reports citing this reaction
17.1%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
35
Total Reports
6
Deaths
17.1%
Death Rate

Species Most Affected

Dog 26
Horse 6
Human 1
Goat 1
Cat 1

Breeds Most Affected

Retriever - Labrador 3
Terrier - West Highland White 2
Quarter Horse 2
Oldenburg 2
Poodle - Miniature 2
Terrier - Yorkshire 2
Crossbred Canine/dog 2
Siberian Husky 2
Pug 1
Shih Tzu 1

Associated Drugs

Carprofen 6
Bedinvetmab 5
Milbemycin Oxime + Spinosad 4
Oclacitinib Maleate 3
Hyaluronic Acid 3
Fluralaner Chew Tablets 3
Triamcinolone Acetonide 2
Hyaluronate Sodium 2
Milbemycin Oxime 2
Milbemycin Oxime + Praziquantel 2
Insulin Injectable Vial 2
Gabapentin 2
Firocoxib 57 Mg Chewable 1
Selamectin 1
Levothyroxine Sodium 1
Clodronate Disodium 1
Florfenicol Inj Sol 30% W Pg 1
Ivermectin 1
Phenylpropanolamine Hydrochloride 1
Unspecified Joint And Ligament Supplement 1

Joint cartilage disorder NOS Reaction Insights

35 reports name Joint cartilage disorder NOS; 6 recorded a death outcome (17.1% of reported events, not a population-level mortality rate). VeDDRA code: 2243.

By species: Dog (26 reports), Horse (6 reports), Human (1 reports). By breed: Retriever - Labrador (3), Terrier - West Highland White (2), Quarter Horse (2).

Most co-reported drugs: Carprofen (6 reports), Bedinvetmab (5 reports), Milbemycin Oxime + Spinosad (4 reports), Oclacitinib Maleate (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.