Reaction profile

The FDA adverse-event record for intestinal congestion

43 FDA adverse-event reports reference intestinal congestion (VeDDRA 326). See the species, breeds, and drugs most associated with it below.

43
reports citing this reaction
72.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
43
Total Reports
31
Deaths
72.1%
Death Rate

Species Most Affected

Dog 29
Cattle 5
Cat 3
Pig 3
Chicken 1
Turkey 1
Horse 1

Breeds Most Affected

Retriever - Labrador 3
Crossbred Canine/dog 3
Boxer (German Boxer) 3
Terrier - Yorkshire 2
Domestic Shorthair 2
Holstein-Friesian also known as Holstein 2
Pit Bull 2
Dachshund - Miniature 2
Persian 1
Rottweiler 1

Associated Drugs

Milbemycin Oxime + Spinosad 10
Fluralaner Chew Tablets 5
Spinosad 4
Monensin Sodium 4
Ivermectin + Pyrantel As Pamoate Salt 4
Firocoxib 227 Mg Chewable 3
Rabies Vaccine 3
Pyrantel Pamoate 2
Dhlpp Vaccine 2
Grapiprant 2
Porcine Reproductive And Respiratory Syndrome (Respiratory Form) Modified Live Virus Vaccine 2
Live Attenuated Porcine Reproductive + Respiratory Syndrome Virus (Prrsv) Strain 2
Vitamin E 2
Emodepside + Praziquantel 1
Praziquantel + Pyrantel 1
Hygromycin B 1
Hyposensitization Injections 1
S-Adenosylmethionine 1
Diphenhydramine 1
Ivermectin 1

Intestinal congestion Reaction Insights

43 reports name Intestinal congestion; 31 recorded a death outcome (72.1% of reported events, not a population-level mortality rate). VeDDRA code: 326.

By species: Dog (29 reports), Cattle (5 reports), Cat (3 reports). By breed: Retriever - Labrador (3), Crossbred Canine/dog (3), Boxer (German Boxer) (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (10 reports), Fluralaner Chew Tablets (5 reports), Spinosad (4 reports), Monensin Sodium (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.