Reaction profile

The FDA adverse-event record for injection site joint reaction

32 FDA adverse-event reports reference injection site joint reaction (VeDDRA 1543). See the species, breeds, and drugs most associated with it below.

32
reports citing this reaction
3.1%
death-coded share
Horse
most-affected species
Hyaluronate Sodium
most-associated drug
Verify with FDA CVM →
32
Total Reports
1
Deaths
3.1%
Death Rate

Species Most Affected

Horse 25
Dog 6
Human 1

Breeds Most Affected

Quarter Horse 6
Horse (unknown) 6
Warmblood (unspecified) 4
Oldenburg 2
Thoroughbred 2
Unknown 1
Terrier - Bull 1
Crossbred Equine/horse 1
Dog (unknown) 1
Standardbred (unspecified) 1

Associated Drugs

Hyaluronate Sodium 16
Triamcinolone Acetonide 12
Betavet 4
Carprofen 2
Gentamicin 2
Moxidectin 2
Tigilanol Tiglate 2
Sometribove Zinc Suspension 1
Analgesic 1
Chondroitin, Glucosamine 1
Human Betamethasone 1
Hyaluronic Acid 1
Melarsomine Dihydrochloride 1
Kenalog 1
Methylprednisolone Acetate 1
Dexmedetomidine 1
Firocoxib 1
Butorphanol 1
Detomidine 1
Xylazine 1

Injection site joint reaction Reaction Insights

32 reports name Injection site joint reaction; 1 recorded a death outcome (3.1% of reported events, not a population-level mortality rate). VeDDRA code: 1543.

By species: Horse (25 reports), Dog (6 reports), Human (1 reports). By breed: Quarter Horse (6), Horse (unknown) (6), Warmblood (unspecified) (4).

Most co-reported drugs: Hyaluronate Sodium (16 reports), Triamcinolone Acetonide (12 reports), Betavet (4 reports), Carprofen (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.