Reaction profile

The FDA adverse-event record for injection site blister

21 FDA adverse-event reports reference injection site blister (VeDDRA 75). See the species, breeds, and drugs most associated with it below.

21
reports citing this reaction
9.5%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
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21
Total Reports
2
Deaths
9.5%
Death Rate

Species Most Affected

Dog 11
Cat 4
Horse 4
Cattle 1
Pig 1

Breeds Most Affected

Crossbred Canine/dog 2
Chihuahua 2
Spaniel - Cocker American 2
Terrier (unspecified) 1
Sphynx 1
Cattle (unknown) 1
Dachshund (unspecified) 1
Warmblood (unspecified) 1
Pig (unknown) 1
Abyssinian cat 1

Associated Drugs

Tigilanol Tiglate 4
Ceftiofur Crystalline Free Acid 3
Butorphanol 2
Diphenhydramine 2
Dexmedetomidine Hydrochloride 2
Prednisone 2
Gabapentin 2
Amantadine 2
Melarsomine Dihydrocloride Injectable 25Mg/Ml 1
Enrofloxacin 1
Saline 1
Melarsomine Dihydrochloride Injection 1
Eprinomectin 5% Injection 1
Cefovecin 1
Canine Rabies Vaccine 1
Canine Vaccine 1
Caninie Vaccine 1
Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg 1
Tulathromycin 1
Meloxicam 1

Injection site blister Reaction Insights

21 reports name Injection site blister; 2 recorded a death outcome (9.5% of reported events, not a population-level mortality rate). VeDDRA code: 75.

By species: Dog (11 reports), Cat (4 reports), Horse (4 reports). By breed: Crossbred Canine/dog (2), Chihuahua (2), Spaniel - Cocker American (2).

Most co-reported drugs: Tigilanol Tiglate (4 reports), Ceftiofur Crystalline Free Acid (3 reports), Butorphanol (2 reports), Diphenhydramine (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.