Reaction profile

The FDA adverse-event record for injection site blister

Name: Injection site blister - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

23 FDA reports name injection site blister, a lower-volume reaction in the CVM extract (VeDDRA 75). Plate stamps and neighbourhood peers follow.

#2110 of 2,481
by report volume (all reactions): 23
reports citing this reaction: 8.7%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Injection site blister has 23 reports now versus 21 in that prior snapshot: 2 more (9.5%).

Report change: +2
Death-coded reports: +0
Death-coded share: −0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Injection site blister changes

FDA AER · VeDDRA plate

Code 75 VOL-TRACE

VOL-TRACE · DEATH-PAR · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 23 reports
DEATH-PAR 8.7%
LOWER-Q #2110/2481
PHOTO-FINISH Anal oedema
SPECIES-DOG Dog · 13
DRUG-LEAD Tigilanol Tiglate · 4
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anal oedema (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Injection site blister

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Injection site blister

What the FDA AER plate says about Injection site blister

Signature read: 23 reports place Injection site blister in the lower third of FDA AER volume (#2110 of 2,481). Report volume is lower-third scale: 23 named reports in the openFDA extract. 2 of 23 reports were death-coded (8.7% of named reports, not a population mortality rate). Nearest volume peer: Anal oedema (±0 reports). Lead species Dog (13). Lead co-reported drug Tigilanol Tiglate (4).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Tigilanol Tiglate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 13

Cat 4

Horse 4

Cattle 1

Pig 1

Breeds Most Affected

Crossbred Canine/dog 2

Chihuahua 2

Spaniel - Cocker American 2

Terrier (unspecified) 1

Sphynx 1

Cattle (unknown) 1

Dachshund (unspecified) 1

Warmblood (unspecified) 1

Pig (unknown) 1

Abyssinian cat 1

Associated Drugs

Tigilanol Tiglate 4

Ceftiofur Crystalline Free Acid 3

Butorphanol 2

Dexmedetomidine Hydrochloride 2

Prednisone 2

Gabapentin 2

Diphenhydramine 2

Maropitant Citrate 2

Amantadine 2

Melarsomine Dihydrocloride Injectable 25Mg/Ml 1

Enrofloxacin 1

Saline 1

Melarsomine Dihydrochloride Injection 1

Eprinomectin 5% Injection 1

Cefovecin 1

Canine Rabies Vaccine 1

Canine Vaccine 1

Caninie Vaccine 1

Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg 1

Tulathromycin 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Injection site blister (#2110 of 2,481 by report volume); death-coded 8.7%. PlainBreed reaction plate · report volume stamp 23 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →