Reaction profile

The FDA adverse-event record for ineffective, parasite(s)

18 FDA adverse-event reports reference ineffective, parasite(s) (VeDDRA 99134). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
11.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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18
Total Reports
2
Deaths
11.1%
Death Rate

Species Most Affected

Dog 10
Cattle 5
Cat 1
Chicken 1
Bison 1

Breeds Most Affected

Dog (unknown) 7
Cattle (unknown) 2
Crossbred Canine/dog 2
Retriever - Golden 1
Cat (other) 1
Holstein-Friesian also known as Holstein 1
Chicken (unknown) 1
American bison 1
Cattle (other) 1
Mixed (Cattle) 1

Associated Drugs

Milbemycin Oxime + Spinosad 8
Eprinomectin 3
Ivermectin 2
Selamectin 1
Fenbendazol Granules 1
Tylosin 1
Bovine Parainfluenza 3 Virus, Killed Virus + Bovine Respiratory Syncytial Virus, Killed Virus + Bovine Rhinotracheitis Virus, Killed Virus + Bovine Virus Diarrhea Type 1, Killed Virus + Bovine Virus Diarrhea Type 2, Killed Virus + Leptospira Canicola Bacterin + Leptospira Grippotyphosa Bacterin + Leptospira Hardjo Bacterin + Leptospira Icterohaemorrhagiae Bacterin + Leptospira Pomona Bacterin 1
Clostridium Chauvoei + Clostridium Haemolyticum + Clostridium Novyi + Clostridium Perfringens Type C + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii 1
Spinosad 1
Doramectin 1

INEFFECTIVE, PARASITE(S) Reaction Insights

18 reports name INEFFECTIVE, PARASITE(S); 2 recorded a death outcome (11.1% of reported events, not a population-level mortality rate). VeDDRA code: 99134.

By species: Dog (10 reports), Cattle (5 reports), Cat (1 reports). By breed: Dog (unknown) (7), Cattle (unknown) (2), Crossbred Canine/dog (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (8 reports), Eprinomectin (3 reports), Ivermectin (2 reports), Selamectin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.