Reaction profile

The FDA adverse-event record for increased skin temperature

32 FDA reports name increased skin temperature, a lower-volume reaction in the CVM extract (VeDDRA 2691). Plate stamps and neighbourhood peers follow.

#1960 of 2,481
by report volume (all reactions)
32
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Increased skin temperature has 32 reports now versus 32 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Increased skin temperature changes

FDA AER · VeDDRA plate

Code 2691 VOL-TRACE

VOL-TRACE · DEATH-PAR · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 32 reports
  • DEATH-PAR 6.3%
  • LOWER-Q #1960/2481
  • PHOTO-FINISH ANION GAP HI, BLD
  • SPECIES-DOG Dog · 22
  • DRUG-LEAD Prednisone · 5
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ANION GAP HI, BLD (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Increased skin temperature

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ANION GAP HI, BLD · near32Application site haem… · near32Convulsive disorder N… · near32Copper toxicity signs · near32Increased skin temper… · thi…32Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Increased skin temperature

Increased skin temperature: low death-coded share in the FDA AER plate

Signature read: 2 death-coded reports is a thin tail count for Increased skin temperature in the CVM extract. Report volume is lower-third scale: 32 named reports in the openFDA extract. Death-coded share is lower-third: 2 of 32 reports (6.3% of named reports). Nearest volume peer: ANION GAP HI, BLD (±0 reports). Lead species Dog (22). Lead co-reported drug Prednisone (5).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Prednisone appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 22
Cat 7
Horse 2
Human 1

Breeds Most Affected

Retriever - Labrador 3
Retriever - Golden 3
Domestic Longhair 2
Terrier - Jack Russell 2
Cat (other) 2
Domestic Shorthair 2
Shepherd Dog - German 2
Collie - Border 2
Bichon Frise 1
Crossbred Canine/dog 1

Associated Drugs

Prednisone 5
Moxidectin 4
Gabapentin 4
Selamectin;Sarolaner 3
Trilostane 3
Isoflurane 3
Pyrantel Pamoate;Sarolaner 3
Ondansetron 3
Sarolaner 2
Cefovecin 2
Anti-Il31 Mab Mcs Lot #1283563 2
Fluralaner 5.46% 1-Month Chew 2
Buprenorphine 2
Famotidine 2
Bedinvetmab 2
Maropitant Citrate 2
Pain Meds (Unknown) 2
Fluid Therapy 2
Antibiotic (Unknown) 2
Gentamicin, Betamethasone, Miconazole 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Increased skin temperature (#1960 of 2,481 by report volume); death-coded 6.3%. PlainBreed reaction plate · death-coded report count stamp 2 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →