Reaction profile

The FDA adverse-event record for increased skin temperature

31 FDA adverse-event reports reference increased skin temperature (VeDDRA 2691). See the species, breeds, and drugs most associated with it below.

31
reports citing this reaction
6.5%
death-coded share
Dog
most-affected species
Prednisone
most-associated drug
Verify with FDA CVM →
31
Total Reports
2
Deaths
6.5%
Death Rate

Species Most Affected

Dog 21
Cat 7
Horse 2
Human 1

Breeds Most Affected

Retriever - Labrador 3
Retriever - Golden 3
Domestic Longhair 2
Terrier - Jack Russell 2
Cat (other) 2
Domestic Shorthair 2
Shepherd Dog - German 2
Bichon Frise 1
Crossbred Canine/dog 1
Beagle 1

Associated Drugs

Prednisone 5
Moxidectin 4
Gabapentin 4
Selamectin;Sarolaner 3
Trilostane 3
Isoflurane 3
Ondansetron 3
Sarolaner 2
Cefovecin 2
Anti-Il31 Mab Mcs Lot #1283563 2
Fluralaner 5.46% 1-Month Chew 2
Buprenorphine 2
Pyrantel Pamoate;Sarolaner 2
Bedinvetmab 2
Famotidine 2
Maropitant Citrate 2
Pain Meds (Unknown) 2
Fluid Therapy 2
Antibiotic (Unknown) 2
Gentamicin, Betamethasone, Miconazole 2

Increased skin temperature Reaction Insights

31 reports name Increased skin temperature; 2 recorded a death outcome (6.5% of reported events, not a population-level mortality rate). VeDDRA code: 2691.

By species: Dog (21 reports), Cat (7 reports), Horse (2 reports). By breed: Retriever - Labrador (3), Retriever - Golden (3), Domestic Longhair (2).

Most co-reported drugs: Prednisone (5 reports), Moxidectin (4 reports), Gabapentin (4 reports), Selamectin;Sarolaner (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.