Reaction profile

The FDA adverse-event record for anion gap hi, bld

31 FDA adverse-event reports reference anion gap hi, bld (VeDDRA 99188). See the species, breeds, and drugs most associated with it below.

31
reports citing this reaction
29.0%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
31
Total Reports
9
Deaths
29.0%
Death Rate

Species Most Affected

Dog 22
Cat 7
Pig 1
Horse 1

Breeds Most Affected

Domestic Shorthair 4
Poodle (unspecified) 2
Crossbred Canine/dog 2
Terrier - Yorkshire 2
Spaniel - Springer (unspecified) 1
Domestic (unspecified) 1
Setter - Irish Red 1
Ridgeback - Rhodesian 1
Retriever - Golden 1
Poodle - Toy 1

Associated Drugs

Spinosad 5
Meloxicam 3
Desoxycorticosterone Pivalate 3
Bexagliflozin 3
Milbemycin Oxime + Spinosad 2
Polysulfated Glycosaminoglycan 2
Carprofen 1
Cyclosporine A 1
Firocoxib 1
Firocoxib 227 Mg Chewable 1
Trilostane 1
Deracoxib 1
Fluralaner Chew Tablets 1
Alprazolam 1
Ivermectin/Pyrantel 1
Fipronil 1
Prednisone 1
Ivermectin + Pyrantel 1
Insulin Injectable Vial 1
Fluralaner Spot-On Solution 1

ANION GAP HI, BLD Reaction Insights

31 reports name ANION GAP HI, BLD; 9 recorded a death outcome (29.0% of reported events, not a population-level mortality rate). VeDDRA code: 99188.

By species: Dog (22 reports), Cat (7 reports), Pig (1 reports). By breed: Domestic Shorthair (4), Poodle (unspecified) (2), Crossbred Canine/dog (2).

Most co-reported drugs: Spinosad (5 reports), Meloxicam (3 reports), Desoxycorticosterone Pivalate (3 reports), Bexagliflozin (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.