Reaction profile

The FDA adverse-event record for anion gap hi, bld

32 FDA reports name anion gap hi, bld, a lower-volume reaction in the CVM extract (VeDDRA 99188). Plate stamps and neighbourhood peers follow.

#1951 of 2,481
by report volume (all reactions)
32
reports citing this reaction
31.3%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. ANION GAP HI, BLD has 32 reports now versus 31 in that prior snapshot: 1 more (3.2%).

Report change
+1
Death-coded reports
+1
Death-coded share
+2.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to ANION GAP HI, BLD changes

FDA AER · VeDDRA plate

Code 99188 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 32 reports
  • DEATH-HOT 31.3%
  • LOWER-Q #1951/2481
  • PHOTO-FINISH Application site haem…
  • SPECIES-DOG Dog · 22
  • DRUG-LEAD Spinosad · 5
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site haemorrhage (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around ANION GAP HI, BLD

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ANION GAP HI, BLD · this rea…32Application site haem… · near32Convulsive disorder N… · near32Copper toxicity signs · near32Dysmetria · near32Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around ANION GAP HI, BLD

ANION GAP HI, BLD: high death-coded share in the FDA AER plate

Signature read: 32 reports place ANION GAP HI, BLD in the lower third of FDA AER volume (#1951 of 2,481). Report volume is lower-third scale: 32 named reports in the openFDA extract. Death-coded share is upper-third: 10 of 32 reports (31.3% of named reports). Nearest volume peer: Application site haemorrhage (±0 reports). Lead species Dog (22). Lead co-reported drug Spinosad (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 22
Cat 8
Pig 1
Horse 1

Breeds Most Affected

Domestic Shorthair 4
Poodle (unspecified) 2
Crossbred Canine/dog 2
Terrier - Yorkshire 2
Spaniel - Springer (unspecified) 1
Domestic (unspecified) 1
Setter - Irish Red 1
Ridgeback - Rhodesian 1
Retriever - Golden 1
Poodle - Toy 1

Associated Drugs

Spinosad 5
Meloxicam 3
Desoxycorticosterone Pivalate 3
Bexagliflozin 3
Milbemycin Oxime + Spinosad 2
Polysulfated Glycosaminoglycan 2
Carprofen 1
Cyclosporine A 1
Firocoxib 1
Firocoxib 227 Mg Chewable 1
Trilostane 1
Deracoxib 1
Fluralaner Chew Tablets 1
Alprazolam 1
Ivermectin/Pyrantel 1
Fipronil 1
Prednisone 1
Ivermectin + Pyrantel 1
Insulin Injectable Vial 1
Fluralaner Spot-On Solution 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for ANION GAP HI, BLD (#1951 of 2,481 by report volume); death-coded 31.3%. PlainBreed reaction plate · report volume stamp 32 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →